Evidence map›Paper›PMID 38896803›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

A Non-Coding Oligonucleotide Recruits Cutaneous CD11b

Kahkashan Kamal, Elina Richardsdotter-Andersson, Aleksandra Dondalska, Marie Wahren-Herlenius, Anna-Lena Spetz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. A Non-Coding Oligonucleotide Recruits Cutaneous CD11bAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kahkashan KamalDepartment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Svante Arrhenius väg 20C, Stockholm, SE-106 91, Sweden.ORCID 0000-0003-0968-7454
Elina Richardsdotter-AnderssonDepartment of Medicine, Karolinska University Hospital, Karolinska Institutet, Visionsgatan 18, L8, Solna, SE-171 76, Sweden.ORCID 0009-0003-7008-529X
Aleksandra DondalskaDepartment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Svante Arrhenius väg 20C, Stockholm, SE-106 91, Sweden.ORCID 0000-0003-3259-634X
Marie Wahren-HerleniusDepartment of Medicine, Karolinska University Hospital, Karolinska Institutet, Visionsgatan 18, L8, Solna, SE-171 76, Sweden.ORCID 0000-0002-0915-7245
Anna-Lena SpetzDepartment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Svante Arrhenius väg 20C, Stockholm, SE-106 91, Sweden.ORCID 0000-0003-3964-9512

Funding

Stockholm UniversitySwedish Research Council 2020-01730
6 · The paper itself

Abstract

Skin-resident antigen-presenting cells (APC) play an important role in maintaining peripheral tolerance via immune checkpoint proteins and induction of T regulatory cells (Tregs). However, there is a lack of knowledge on how to expand or recruit immunoregulatory cutaneous cells without causing inflammation. Here, it is shown that administration of a non-coding single-stranded oligonucleotide (ssON) leads to CCR2-dependent accumulation of CD45

Indexed as

CD11b AntigenSkinT-Lymphocytes, RegulatoryAnimalsAntigen-Presenting CellsB7-H1 AntigenDisease Models, AnimalFemaleMiceMice, Inbred C57BLOligonucleotidesB7-H1 AntigenCD11b AntigenOligonucleotidesantigen‐presenting cellscytokinesoligonucleotidesprogrammed‐death ligand 1skinT helper cells

Identifiers

PMID38896803
PMCPMC11336929

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.