Evidence map›Paper›PMID 38896780›Full record

ArticleEnvironmental health perspectives2024

Prolonged Cadmium Exposure and Osteoclastogenesis: A Mechanistic Mouse and

Zhiyuan Liu, Jinzhi Wu, Zhe Dong, Yanshuai Wang, Gang Wang, Chengjie Chen, Huihui Wang, Yang Yang, Yongxin Sun, Maowei Yang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health perspectives, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Airborne contaminant exposure and bone development: a systematic review and meta-analysis.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zhiyuan LiuKey Laboratory of Environmental Stress and Chronic Disease Control and Prevention, Ministry of Education, China Medical University, Shenyang, Liaoning, P.R. China.
Jinzhi WuKey Laboratory of Environmental Stress and Chronic Disease Control and Prevention, Ministry of Education, China Medical University, Shenyang, Liaoning, P.R. China.
Zhe DongKey Laboratory of Environmental Stress and Chronic Disease Control and Prevention, Ministry of Education, China Medical University, Shenyang, Liaoning, P.R. China.
Yanshuai WangKey Laboratory of Environmental Stress and Chronic Disease Control and Prevention, Ministry of Education, China Medical University, Shenyang, Liaoning, P.R. China.
Gang WangKey Laboratory of Environmental Stress and Chronic Disease Control and Prevention, Ministry of Education, China Medical University, Shenyang, Liaoning, P.R. China.
Chengjie ChenKey Laboratory of Environmental Stress and Chronic Disease Control and Prevention, Ministry of Education, China Medical University, Shenyang, Liaoning, P.R. China.
Huihui WangKey Laboratory of Environmental Stress and Chronic Disease Control and Prevention, Ministry of Education, China Medical University, Shenyang, Liaoning, P.R. China.
Yang YangDepartment of Rehabilitation Medicine, First Hospital of China Medical University, Shenyang, Liaoning, P.R. China.
Yongxin SunDepartment of Rehabilitation Medicine, First Hospital of China Medical University, Shenyang, Liaoning, P.R. China.
Maowei YangDepartment of Orthopedics, First Hospital of China Medical University, Shenyang, Liaoning, P.R. China.
Jingqi FuKey Laboratory of Environmental Stress and Chronic Disease Control and Prevention, Ministry of Education, China Medical University, Shenyang, Liaoning, P.R. China.
Jiliang LiDepartment of Biology, Indiana University Indianapolis, Indianapolis, Indiana, USA.
Qiang ZhangGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Yuanyuan XuKey Laboratory of Environmental Stress and Chronic Disease Control and Prevention, Ministry of Education, China Medical University, Shenyang, Liaoning, P.R. China.
Jingbo PiKey Laboratory of Environmental Stress and Chronic Disease Control and Prevention, Ministry of Education, China Medical University, Shenyang, Liaoning, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCadmium (Cd) is a highly toxic and widespread environmental oxidative stressor that causes a myriad of health problems, including osteoporosis and bone damage. Although nuclear factor erythroid 2-related factor 2 (NRF2) and its Cap 'n' Collar and basic region Leucine Zipper (CNC-bZIP) family member nuclear factor erythroid 2-related factor 1 (NRF1) coordinate various stress responses by regulating the transcription of a variety of antioxidant and cytoprotective genes, they play distinct roles in bone metabolism and remodeling. However, the precise roles of both transcription factors in bone loss induced by prolonged Cd exposure remain unclear.

objectivesWe aimed to understand the molecular mechanisms underlying Cd-induced bone loss, focusing mainly on the roles of NRF2 and NRF1 in osteoclastogenesis provoked by Cd.

methodsMale wild-type (WT), global

resultsCompared with relevant control mice, global

conclusionsThis

Indexed as

CadmiumNF-E2-Related Factor 2OsteoclastsOsteogenesisAnimalsCell DifferentiationMaleMiceMice, Inbred C57BLMice, KnockoutNF-E2-Related Factor 1CadmiumNfe2l2 protein, mouseNF-E2-Related Factor 1NF-E2-Related Factor 2

Identifiers

PMID38896780
PMCPMC11218709

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.