Evidence map›Paper›PMID 38896611›Full record

ArticleScience advances2024

Noninvasive assessment of the lung inflammation-fibrosis axis by targeted imaging of CMKLR1.

Philip Z Mannes, Taylor S Adams, Samaneh Farsijani, Clayton E Barnes, Joseph D Latoche, Kathryn E Day, Jessie R Nedrow, Farida Ahangari, Naftali Kaminski, Janet S Lee and 1 more

Abstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Next-generation molecular imaging of cardiac fibrosis.The international journal of cardiovascular imaging · 2026
    Review
  2. Article
  3. Article
  4. The transcriptome of CD14The European respiratory journal · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. [Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
    Article
  10. Review
  11. Molecular Imaging of Pulmonary Fibrosis.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Philip Z MannesDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-3080-8863
Taylor S AdamsSection of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-4280-9070
Samaneh FarsijaniDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-0671-4392
Clayton E BarnesDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-8943-7564
Joseph D LatocheDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-4800-5623
Kathryn E DayDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Jessie R NedrowDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-3465-1296
Farida AhangariSection of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-4144-9395
Naftali KaminskiSection of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0001-5917-4601
Janet S LeeDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University, St. Louis, MO, USA.ORCID 0000-0002-6812-6043
Sina TavakoliDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-0574-3914

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Leonard J. Appleman · 1988 to 2026
$158.0M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Regulation of Cardiolin Byosynthesis in Epithelial InjuryP01HL114453 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCVERRY, BRYAN J · 2014 to 2023
$21.3M
Genomic Analysis of Tissue and Cellular Heterogeneity in IPFR01HL127349 · NHLBI · YALE UNIVERSITY · PI BENOS, PANAGIOTIS V, KAMINSKI, NAFTALI · 2015 to 2025
$5.9M
Mechanisms of host protection against pathogen-secreted proteases in acute lung injuryR01HL136143 · NHLBI · WASHINGTON UNIVERSITY · PI LEE, JANET SOJUNG · 2017 to 2024
$4.4M
Epithelial Protective Effects of Thyroid Hormone Signaling in FibrosisR01HL141852 · NHLBI · YALE UNIVERSITY · PI KAMINSKI, NAFTALI · 2019 to 2022
$3.4M
Normal Aging Lung Cell Atlas (NALCA)U01HL145567 · NHLBI · YALE UNIVERSITY · PI KAMINSKI, NAFTALI · 2019 to 2022
$2.8M
Mir-29 mimicry as a therapy for pulmonary fibrosisUH2HL123886 · NHLBI · YALE UNIVERSITY · PI KAMINSKI, NAFTALI · 2014 to 2015
$2.7M
CMKLR1-Targeted Molecular Imaging of Inflammation as a Precision Medicine Tool in Acute Lung Injury and Fibrotic Lung DiseasesR01HL166953 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sina Tavakoli · 2023 to 2026
$2.4M
The role of ACOD1 in immunomodulation in intrapulmonary Klebsiella pneumoniae infectionR01HL142084 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, KONG · 2018 to 2021
$2.4M
Spatiotemporal control of early matricellular events in the injured lungR01HL177904 · NHLBI · WASHINGTON UNIVERSITY · PI Jaehyung Cho, Janet Sojung Lee · 2025 to 2026
$1.5M
A Molecular Imaging Approach to Immuno-Metabolic Characterization of Vessel Wall MacrophagesK08HL144911 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TAVAKOLI, SINA · 2019 to 2023
$813k
NCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA047904NHLBI NIH HHS F30 HL158038NHLBI NIH HHS K08 HL144911NHLBI NIH HHS K24 HL143285NHLBI NIH HHS P01 HL114453NHLBI NIH HHS R01 HL127349NHLBI NIH HHS R01 HL136143NHLBI NIH HHS R01 HL141852NHLBI NIH HHS R01 HL142084NHLBI NIH HHS R01 HL166953NHLBI NIH HHS R01 HL177904NHLBI NIH HHS U01 HL145567NHLBI NIH HHS UH2 HL123886NIA NIH HHS K01 AG071855NIBIB NIH HHS R21 EB027871
6 · The paper itself

Abstract

Precision management of fibrotic lung diseases is challenging due to their diverse clinical trajectories and lack of reliable biomarkers for risk stratification and therapeutic monitoring. Here, we validated the accuracy of CMKLR1 as an imaging biomarker of the lung inflammation-fibrosis axis. By analyzing single-cell RNA sequencing datasets, we demonstrated

Indexed as

Idiopathic Pulmonary FibrosisPneumoniaAnimalsBiomarkersBleomycinDisease Models, AnimalFemaleHumansLungMacrophagesMaleMiceMice, Inbred C57BLPositron-Emission TomographyPulmonary FibrosisBiomarkersBleomycin

Identifiers

PMID38896611
PMCPMC11186491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.