ArticleScience translational medicine2024
A bioadhesive pacing lead for atraumatic cardiac monitoring and stimulation in rodent and porcine models.
Article in Science translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Soft robotic devices for cardiovascular medicine.Nature reviews. Cardiology · 2026Review
- 3D-Printed Bioadhesive Interfaces as Proliferative Niches for Tissue Repair.Cell proliferation · 2026Review
- Minimally invasive bioelectronic implants.Nature materials · 2026Review
- A wearable acoustofluidic patch for rapid reversal of opioid overdose.Nature communications · 2026Article
- 3D-printed implantable bioelectronics enabled by anti-swelling and biphasic conductive hydrogels.Nature materials · 2026Article
- Fully Wireless and Flexible Valves for Multiplexed and Prolonged Intravesical Liquid Release.Advanced healthcare materials · 2026Article
- Hydrogel-integrated multimodal physiological and modulation systems.Materials horizons · 2026Review
- Controlling thermoreversibility and hole conductivity in thermoresponsive ionic biogels using phase morphology for neurohaptics.Science advances · 2026Article
- Soft, Flexible, and Stretchable Platforms for Tissue-Interfaced Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Activation of the YAP1/pSTAT3/NRP1 axis in peritendinous sensory nerves promotes tendon healing.Science advances · 2026Article
- Soft sonocapacitor with topologically integrated piezodielectric nanospheres enables wireless epidural closed-loop neuromodulation.Nature communications · 2026Article
- Facile and robust integration of functional hydrogels into micropillar-structured elastomer platforms for stable cardiac bioelectronics.Science advances · 2026Article
- Thermo-reversible gelation of self-assembled conducting polymer colloids.Nature communications · 2025Article
- Spatially Programmable Electroadhesive Enables In Situ Site-Selective Functional Coupling.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Zwitterionic hydrogel designs for conducting polymers enable bioelectronics with suppressed foreign body responses.bioRxiv : the preprint server for biology · 2025Article
- Materials Advances in Devices for Heart Disease Interventions.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- A reusable hydrogel biosensor array with electrically responsive hydrogel interfaces for noninvasive locating of perforating arteries.Science advances · 2025Article
- Bioinspired hydrogel for sustained minocycline release: A superior periodontitis solution.Materials today. Bio · 2025Article
- Novel Electroactive Therapeutic Platforms for Cardiac Arrhythmia Management.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Polyelectrolyte-based wireless and drift-free iontronic sensors for orthodontic sensing.Science advances · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Current clinically used electronic implants, including cardiac pacing leads for epicardial monitoring and stimulation of the heart, rely on surgical suturing or direct insertion of electrodes to the heart tissue. These approaches can cause tissue trauma during the implantation and retrieval of the pacing leads, with the potential for bleeding, tissue damage, and device failure. Here, we report a bioadhesive pacing lead that can directly interface with cardiac tissue through physical and covalent interactions to support minimally invasive adhesive implantation and gentle on-demand removal of the device with a detachment solution. We developed 3D-printable bioadhesive materials for customized fabrication of the device by graft-polymerizing polyacrylic acid on hydrophilic polyurethane and mixing with poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) to obtain electrical conductivity. The bioadhesive construct exhibited mechanical properties similar to cardiac tissue and strong tissue adhesion, supporting stable electrical interfacing. Infusion of a detachment solution to cleave physical and covalent cross-links between the adhesive interface and the tissue allowed retrieval of the bioadhesive pacing leads in rat and porcine models without apparent tissue damage. Continuous and reliable cardiac monitoring and pacing of rodent and porcine hearts were demonstrated for 2 weeks with consistent capture threshold and sensing amplitude, in contrast to a commercially available alternative. Pacing and continuous telemetric monitoring were achieved in a porcine model. These findings may offer a promising platform for adhesive bioelectronic devices for cardiac monitoring and treatment.
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Registered trials
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