Evidence map›Paper›PMID 38896551›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2024

Structural connectivity changes in unilateral hearing loss.

Pascale Tsai, Timur H Latypov, Peter Shih-Ping Hung, Aisha Halawani, Patcharaporn Srisaikaew, Matthew R Walker, Ashley B Zhang, Wanzhang Wang, Fatemeh Hassannia, Rana Barake and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Pascale TsaiKrembil Research Institute, University Health Network, 60 Leonard Ave, Toronto, Ontario M5T 0S8, Canada.ORCID 0000-0001-6897-6331
Timur H LatypovKrembil Research Institute, University Health Network, 60 Leonard Ave, Toronto, Ontario M5T 0S8, Canada.ORCID 0000-0002-8501-6890
Peter Shih-Ping HungKrembil Research Institute, University Health Network, 60 Leonard Ave, Toronto, Ontario M5T 0S8, Canada.
Aisha HalawaniKrembil Research Institute, University Health Network, 60 Leonard Ave, Toronto, Ontario M5T 0S8, Canada.
Patcharaporn SrisaikaewKrembil Research Institute, University Health Network, 60 Leonard Ave, Toronto, Ontario M5T 0S8, Canada.
Matthew R WalkerKrembil Research Institute, University Health Network, 60 Leonard Ave, Toronto, Ontario M5T 0S8, Canada.
Ashley B ZhangKrembil Research Institute, University Health Network, 60 Leonard Ave, Toronto, Ontario M5T 0S8, Canada.
Wanzhang WangKrembil Research Institute, University Health Network, 60 Leonard Ave, Toronto, Ontario M5T 0S8, Canada.
Fatemeh HassanniaDepartment of Otolaryngology-Head and Neck Surgery, University of Toronto, 600 University Ave, Toronto, Ontario M5G 1X5, Canada.
Rana BarakeDepartment of Otolaryngology-Head and Neck Surgery, University of Toronto, 600 University Ave, Toronto, Ontario M5G 1X5, Canada.
Karen A GordonInstitute of Medical Science, University of Toronto, 6 Queen's Park Cres, Toronto, Ontario M5S 3H2, Canada.
George M IbrahimInstitute of Medical Science, University of Toronto, 6 Queen's Park Cres, Toronto, Ontario M5S 3H2, Canada.
John RutkaDepartment of Otolaryngology-Head and Neck Surgery, University of Toronto, 600 University Ave, Toronto, Ontario M5G 1X5, Canada.
Mojgan HodaieKrembil Research Institute, University Health Network, 60 Leonard Ave, Toronto, Ontario M5T 0S8, Canada.

Funding

CIHR GSD157876Natural Science and Engineering Research CouncilOntario Student Opportunity Trust Fund
6 · The paper itself

Abstract

Network connectivity, as mapped by the whole brain connectome, plays a crucial role in regulating auditory function. Auditory deprivation such as unilateral hearing loss might alter structural network connectivity; however, these potential alterations are poorly understood. Thirty-seven acoustic neuroma patients with unilateral hearing loss (19 left-sided and 18 right-sided) and 19 healthy controls underwent diffusion-weighted and T1-weighted imaging to assess edge strength, node strength, and global efficiency of the structural connectome. Edge strength was estimated by pair-wise normalized streamline density from tractography and connectomics. Node strength and global efficiency were calculated through graph theory analysis of the connectome. Pure-tone audiometry and word recognition scores were used to correlate the degree and duration of unilateral hearing loss with node strength and global efficiency. We demonstrate significantly stronger edge strength and node strength through the visual network, weaker edge strength and node strength in the somatomotor network, and stronger global efficiency in the unilateral hearing loss patients. No discernible correlations were observed between the degree and duration of unilateral hearing loss and the measures of node strength or global efficiency. These findings contribute to our understanding of the role of structural connectivity in hearing by facilitating visual network upregulation and somatomotor network downregulation after unilateral hearing loss.

Indexed as

ConnectomeHearing Loss, UnilateralAdultAgedBrainDiffusion Tensor ImagingFemaleFunctional LateralityHumansMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeural PathwaysNeuroma, Acousticauditoryconnectomegraph theoryimagingnetwork

Identifiers

PMID38896551
PMCPMC12558133

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.