ArticleeLife2024
Abstract read
In one paragraph
Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Article
- Hematologic dysfunction and myeloid neoplasm risk in patients treated with lutetiumHaematologica · 2025Article
- A Recent Overview of Molecular Pathways in Synthetic Lethality as a Proposed Valid Target in Oncology: Current Insights and Future Directions.Indian journal of surgical oncology · 2025Review
- Article
Corrections and comments
- Update of
Authors and funding
24 authors.
Linda ZhangTranslational Biology and Molecular Medicine Graduate Program, Baylor College of Medicine, Houston, United States.ORCID https://orcid.org/0000-0002-5777-2357
Joanne I HsuTranslational Biology and Molecular Medicine Graduate Program, Baylor College of Medicine, Houston, United States.
Etienne D BraekeleerDepartment of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
Chun-Wei ChenStem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Tajhal D PatelTexas Children's Hospital Department of Hematology/Oncology, Baylor College of Medicine, Houston, United States.
Alejandra G MartellDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.
Anna G GuzmanDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.
Katharina WohlanDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.
Sarah M WaldvogelMedical Scientist Training Program, Baylor College of Medicine, Houston, United States.
Hidetaka UryuDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, United States.ORCID https://orcid.org/0000-0001-7167-895X
Ayala TovyStem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Elsa CallenLaboratory of Genome Integrity, National Cancer Institute, National Institute of Health, Bethesda, United States.
Rebecca L MurdaughStem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Rosemary RichardStem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Sandra JansenDonders Centre for Neuroscience, Radboud University Medical Center, Nijmegen, Netherlands.
Lisenka VissersDonders Centre for Neuroscience, Radboud University Medical Center, Nijmegen, Netherlands.
Bert B A de VriesDonders Centre for Neuroscience, Radboud University Medical Center, Nijmegen, Netherlands.
Andre NussenzweigLaboratory of Genome Integrity, National Cancer Institute, National Institute of Health, Bethesda, United States.
Shixia HuangDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.
Cristian CoarfaDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.
Jamie AnastasStem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.
Koichi TakahashiDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, United States.
George VassiliouDepartment of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0003-4337-8022
Margaret A GoodellStem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, United States.ORCID https://orcid.org/0000-0003-1111-2932
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9MRelationship between DNA damage detection and signalingZIABC010959 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NUSSENZWEIG, ANDRE A. · 2009 to 2025
$27.0MDNA RepairZIABC010283 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NUSSENZWEIG, ANDRE A. · 2009 to 2025
$27.0MProject 3: Contribution of inflammation and DNA damaging factors to clonal expansion and malignant transformation in a community cohort of older adultsP01CA265748 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Koichi Takahashi · 2022 to 2026
$13.6MTraining In Cell and Gene TherapyT32HL092332 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI MALCOLM K. BRENNER, Bruno Di Stefano · 2008 to 2026
$6.9MPPM1D in Clonal Hematopoiesis and MalignanciesR01CA237291 · NCI · BAYLOR COLLEGE OF MEDICINE · PI MARGARET A. GOODELL, Koichi Takahashi · 2019 to 2026
$3.7MBD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430kQuanterix 2470 Arrayer for Reverse Phase Protein Array TechnologyS10OD028648 · OD · BAYLOR COLLEGE OF MEDICINE · PI HUANG, SHIXIA · 2020 to 2020
$300kClonal Hematopoiesis, Aging and Genome Stability in PPM1D MutantsU01CA236972 · NCI · BAYLOR COLLEGE OF MEDICINE · PI GOODELL, MARGARET A. · 2019 to 2020
$240kDetermining the effect of DNMT3A loss on the competitive fitness of mutant cells in somatic mosaicismF30HD111129 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sarah Marie Waldvogel · 2023 to 2026
$210kThe Role of WIP1 in Clonal HematopoiesisF30DK116428 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI HSU, JOANNE INO · 2017 to 2019
$118kEunice Kennedy Shriver National Institute of Child Health & Human Development F30HD111129Leukemia and Lymphoma Society Scholar AwardNCI NIH HHS P01 CA265748NCI NIH HHS P01CA265748NCI NIH HHS P30 CA125123NCI NIH HHS P30CA125123NCI NIH HHS R01 CA237291NCI NIH HHS R01CA237291NCI NIH HHS U01 CA236972NCRR NIH HHS S10 RR024574NHLBI NIH HHS T32 HL092332NICHD NIH HHS F30 HD111129NIDDK NIH HHS F30 DK116428NIDDK NIH HHS F30DK116428NIH HHS S10 OD028648
Abstract
The DNA damage response is critical for maintaining genome integrity and is commonly disrupted in the development of cancer. PPM1D (protein phosphatase Mg
Indexed as
Protein Phosphatase 2CSuperoxide Dismutase-1Cell Line, TumorCRISPR-Cas SystemsHumansLeukemiaMutationOxidative StressReactive Oxygen SpeciesSynthetic Lethal MutationsPPM1D protein, humanProtein Phosphatase 2CReactive Oxygen SpeciesSOD1 protein, humanSuperoxide Dismutase-1cancercancer biologycell biologyDNA damageleukemiamouse
Identifiers
What OpenQuestion holds
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LicenceCC0
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.