Evidence map›Paper›PMID 38896448›Full record

ArticleeLife2024

ASAR lncRNAs control DNA replication timing through interactions with multiple hnRNP/RNA binding proteins.

Mathew Thayer, Michael B Heskett, Leslie G Smith, Paul T Spellman, Phillip A Yates

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mathew Thayer *Department of Chemical Physiology and Biochemistry,Oregon Health & Science University, Portland, United States.ORCID https://orcid.org/0000-0001-6483-1661
Michael B Heskett *Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, United States.ORCID https://orcid.org/0000-0003-2089-3910
Leslie G SmithDepartment of Chemical Physiology and Biochemistry,Oregon Health & Science University, Portland, United States.
Paul T SpellmanDepartment of Molecular and Medical Genetics, Oregon Health & Science University, Portland, United States.
Phillip A YatesDepartment of Chemical Physiology and Biochemistry,Oregon Health & Science University, Portland, United States.ORCID https://orcid.org/0000-0003-2016-9789

Funding

The role of ASARs in chromosome dynamicsR01GM130703 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI THAYER, MATHEW J · 2019 to 2022
$1.2M
Control of genetic and epigenetic instabilities by lincRNA genesR01GM114162 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI THAYER, MATHEW J · 2015 to 2018
$1.2M
Integrative Analysis of DNA Replication Timing in CancerK00CA245677 · NCI · STANFORD UNIVERSITY · PI HESKETT, MICHAEL B · 2022 to 2024
$255k
NCI NIH HHS K00 CA245677NIGMS NIH HHS R01 GM114162NIGMS NIH HHS R01GM114162NIGMS NIH HHS R01 GM130703NIGMS NIH HHS R01GM130703
6 · The paper itself

Abstract

ASARs are a family of very-long noncoding RNAs that control replication timing on individual human autosomes, and are essential for chromosome stability. The eight known ASAR lncRNAs remain closely associated with their parent chromosomes. Analysis of RNA-protein interaction data (from ENCODE) revealed numerous RBPs with significant interactions with multiple ASAR lncRNAs, with several hnRNPs as abundant interactors. An ~7 kb domain within the

Indexed as

Heterogeneous-Nuclear RibonucleoproteinsRNA, Long NoncodingDNA Replication TimingHumansProtein BindingRNA-Binding ProteinsHeterogeneous-Nuclear RibonucleoproteinsRNA-Binding ProteinsRNA, Long NoncodingASARchromosomechromosomesgene expressiongeneticsgenomicshumanlong non-coding RNAmouseReplicationRNA bindingXIST

Identifiers

PMID38896448
PMCPMC11186638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.