Evidence map›Paper›PMID 38896357›Full record

ArticleJournal of neuro-oncology2024

Clusters of resilience and vulnerability: executive functioning, coping and mental distress in patients with diffuse low-grade glioma.

Floor Gelmers, Marieke E Timmerman, Femke F Siebenga, Hiska L van der Weide, Sandra E Rakers, Miranda C A Kramer, Anouk van der Hoorn, Roelien H Enting, Ingeborg Bosma, Rob J M Groen and 4 more

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Article in Journal of neuro-oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Floor GelmersDepartment of Clinical Neuropsychology, University of Groningen, University Medical Center Groningen, P.O. Box 30.001, Groningen, AB51, 9700RB, The Netherlands. f.gelmers@umcg.nl.ORCID http://orcid.org/0009-0003-9324-6025
Marieke E TimmermanDepartment of Psychometrics and Statistics, University of Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0003-1579-6964
Femke F SiebengaDepartment of Clinical Neuropsychology, University of Groningen, University Medical Center Groningen, P.O. Box 30.001, Groningen, AB51, 9700RB, The Netherlands.ORCID http://orcid.org/0009-0004-9307-7994
Hiska L van der WeideDepartment of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0001-6734-2345
Sandra E RakersDepartment of Clinical Neuropsychology, University of Groningen, University Medical Center Groningen, P.O. Box 30.001, Groningen, AB51, 9700RB, The Netherlands.ORCID http://orcid.org/0000-0003-1965-9668
Miranda C A KramerDepartment of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Anouk van der HoornDepartment of Radiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0003-4649-327X
Roelien H EntingDepartment of Neurology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-9369-3015
Ingeborg BosmaDepartment of Neurology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Rob J M GroenDepartment of Neurosurgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0003-3067-763X
Hanne-Rinck JeltemaDepartment of Neurosurgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-3529-2707
Michiel WagemakersDepartment of Neurosurgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Jacoba M SpikmanDepartment of Clinical Neuropsychology, University of Groningen, University Medical Center Groningen, P.O. Box 30.001, Groningen, AB51, 9700RB, The Netherlands.ORCID http://orcid.org/0000-0002-6477-0763
Anne M BuunkDepartment of Clinical Neuropsychology, University of Groningen, University Medical Center Groningen, P.O. Box 30.001, Groningen, AB51, 9700RB, The Netherlands.ORCID http://orcid.org/0000-0001-7346-5691

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDiffuse low-grade gliomas (dLGG) often have a frontal location, which may negatively affect patients' executive functions (EF). Being diagnosed with dLGG and having to undergo intensive treatment can be emotionally stressful. The ability to cope with this stress in an adaptive, active and flexible way may be hampered by impaired EF. Consequently, patients may suffer from increased mental distress. The aim of the present study was to explore profiles of EF, coping and mental distress and identify characteristics of each profile.

methods151 patients with dLGG were included. Latent profile analysis (LPA) was used to explore profiles. Additional demographical, tumor and radiological characteristics were included.

resultsFour clusters were found: 1) overall good functioning (25% of patients); 2) poor executive functioning, good psychosocial functioning (32%); 3) good executive functioning, poor psychosocial functioning (18%) and; 4) overall poor functioning (25%). Characteristics of the different clusters were lower educational level and more (micro)vascular brain damage (cluster 2), a younger age (cluster 3), and a larger tumor volume (cluster 4). EF was not a distinctive factor for coping, nor was it for mental distress. Maladaptive coping, however, did distinguish clusters with higher mental distress (cluster 3 and 4) from clusters with lower levels of mental distress (cluster 1 and 2).

conclusionFour distinctive clusters with different levels of functioning and characteristics were identified. EF impairments did not hinder the use of active coping strategies. Moreover, maladaptive coping, but not EF impairment, was related to increased mental distress in patients with dLGG.

Indexed as

Adaptation, PsychologicalBrain NeoplasmsExecutive FunctionGliomaPsychological DistressAdultAgedFemaleHumansMaleMiddle AgedNeoplasm GradingNeuropsychological TestsResilience, PsychologicalStress, PsychologicalYoung AdultAnxietyCopingDepressionExecutive functioningLow-grade glioma

Identifiers

PMID38896357
PMCPMC11269402

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.