Evidence map›Paper›PMID 38896211›Full record

Trial reportCognitive processing2024

APOE genotype, hippocampal volume, and cognitive reserve predict improvement by cognitive training in older adults without dementia: a randomized controlled trial.

Pedro Montejo Carrasco, Mercedes Montenegro-Peña, David Prada Crespo, Inmaculada Rodríguez Rojo, Ana Barabash Bustelo, Borja Montejo Rubio, Alberto Marcos Dolado, Fernando Maestú Unturbe, María Luisa Delgado Losada

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Cognitive processing, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pedro Montejo CarrascoCentre for the Prevention of Cognitive Impairment, Madrid Salud, Madrid City Council, Montesa 22 Building B, 28006, Madrid, Spain.ORCID http://orcid.org/0000-0002-3028-0184
Mercedes Montenegro-PeñaCentre for the Prevention of Cognitive Impairment, Madrid Salud, Madrid City Council, Montesa 22 Building B, 28006, Madrid, Spain. mercedesmontenegro@psi.ucm.es.ORCID http://orcid.org/0000-0003-0264-7329
David Prada CrespoDepartment of Experimental Psychology, Faculty of Psychology, Complutense University, Madrid, Spain.ORCID http://orcid.org/0000-0003-1945-5235
Inmaculada Rodríguez RojoCenter for Cognitive and Computational Neuroscience, Complutense University, Madrid, Spain.ORCID http://orcid.org/0000-0003-2781-3004
Ana Barabash BusteloEndocrinology and Nutrition Department, San Carlos Clinic Hospital, Health Research Institute of the San Carlos Clinic Hospital (IdISSC), Madrid, Spain.ORCID http://orcid.org/0000-0003-2383-1563
Borja Montejo RubioDepartment of Surgery, Ramón y Cajal Hospital, Madrid, Spain.ORCID http://orcid.org/0000-0001-7653-172X
Alberto Marcos DoladoDepartment of Neurology, San Carlos Clinic Hospital, Health Research Institute of the San Carlos Clinic Hospital (IdISSC), Madrid, Spain.ORCID http://orcid.org/0000-0002-3701-1569
Fernando Maestú UnturbeDepartment of Experimental Psychology, Faculty of Psychology, Complutense University, Madrid, Spain.ORCID http://orcid.org/0000-0002-3195-0071
María Luisa Delgado LosadaDepartment of Experimental Psychology, Faculty of Psychology, Complutense University, Madrid, Spain.ORCID http://orcid.org/0000-0001-8808-4613

Funding

Ministerio de Ciencia, Innovación y Universidades PSI2015-68793-C3-3-R
6 · The paper itself

Abstract

Cognitive training (CT) programs aim to improve cognitive performance and impede its decline. Thus, defining the characteristics of individuals who can benefit from these interventions is essential. Our objectives were to assess if the cognitive reserve (CR), APOE genotype (e4 carriers/non-carriers) and/or hippocampal volume might predict the effectiveness of a CT program. Participants were older adults without dementia (n = 226), randomized into parallel experimental and control groups. The assessment consisted of a neuropsychological protocol and additional data regarding total intracranial, gray matter, left/right hippocampus volume; APOE genotype; and Cognitive Reserve (CR). The intervention involved multifactorial CT (30 sessions, 90 min each), with an evaluation pre- and post-training (at six months); the control group simply following the center's routine activities. The primary outcome measures were the change in cognitive performance and the predictors of change. The results show that APOE-e4 non-carriers (79.1%) with a larger left hippocampal volume achieved better gains in semantic verbal fluency (R

Indexed as

Cognitive ReserveHippocampusAgedAged, 80 and overAgingApolipoprotein E4Apolipoproteins ECognitive Behavioral TherapyCognitive DysfunctionCognitive RemediationCognitive TrainingExecutive FunctionFemaleGenotypeHumansMagnetic Resonance ImagingApolipoprotein E4Apolipoproteins EAgeingAPOEBrain volumeCognitive reserveCognitive trainingMemory

Identifiers

PMID38896211

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.