Evidence map›Paper›PMID 38896016›Full record

ReviewCancer medicine2024

The role of ATP-binding cassette subfamily G member 1 in tumor progression.

Xu Xinyi, Yang Gong

Abstract readReview
In one paragraph

Review in Cancer medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Xu XinyiCentral Laboratory, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China.ORCID 0009-0005-3963-0127
Yang GongCentral Laboratory, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China.ORCID 0000-0002-5137-4104

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundATP-binding cassette subfamily G member 1 is mostly known as a transporter for intracellular cholesterol efflux, and a number of studies indicate that ABCG1 also functions actively in tumor initiation and progression. This review aimed to provide an overall review of how ABCG1 acts in tumor progression.

methodA comprehensive searching about ABCG1 and tumor was conducted up to November 2023 using proper keywords through databases including PubMed and Web of Science.

resultOverall, ABCG1 plays a crucial role in the development of multiple tumorigenesis. ABCG1 enhances tumor-promoting ability through conferring stem-like properties to cancer cells and mediates chemoresistance in multiple cancers. Additionally, ABCG1 may act as a kinase to phosphorylate downstream molecules and induces tumor growth. In tumor microenvironment, ABCG1 plays a substantial role in immunity response through macrophages to create a tumor-favoring circumstance.

conclusionHigh expression of ABCG1 is usually associated with poor prognosis, which means ABCG1 may be a potential biomarker for early diagnosis and prognosis of various cancers. ABCG1-targeted therapy may provide a novel treatment for cancer patients.

Indexed as

ATP Binding Cassette Transporter, Subfamily G, Member 1Disease ProgressionDrug Resistance, NeoplasmNeoplasmsTumor MicroenvironmentAnimalsBiomarkers, TumorGene Expression Regulation, NeoplasticHumansPrognosisABCG1 protein, humanATP Binding Cassette Transporter, Subfamily G, Member 1Biomarkers, TumorABCG1chemoresistancestemnesstumor microenvironmenttumor progression

Identifiers

PMID38896016
PMCPMC11187935

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.