Evidence map›Paper›PMID 38895989›Full record

ArticleChemMedChem2024

Sphaeropsidin A C15-C16 Cross-Metathesis Analogues with Potent Anticancer Activity.

Sachin B Wagh, Dino Berthold, Iram Majeed, L Kevin Lewis, David Schilter, Birgit Mertens, Antonio Evidente, Willem A L van Otterlo, Véronique Mathieu, Alexander Kornienko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sachin B WaghDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, Texas, 78666, USA.
Dino BertholdDepartment of Chemistry and Polymer Sciences, Stellenbosch University, Stellenbosch, Matieland, 7602, Western Cape, South Africa.ORCID https://orcid.org/0009-0001-4575-3749
Iram MajeedDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, Texas, 78666, USA.
L Kevin LewisDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, Texas, 78666, USA.
David SchilterDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, Texas, 78666, USA.
Birgit MertensSciensano, Rue Juliette Wytsmanstraat 14, 1050, Brussels, Belgium.
Antonio EvidenteInstitute of Sciences of Food Production, National Research Council, Via Amendola 122/O, 70125, Bari, Italy.
Willem A L van OtterloDepartment of Chemistry and Polymer Sciences, Stellenbosch University, Stellenbosch, Matieland, 7602, Western Cape, South Africa.ORCID https://orcid.org/0000-0002-3300-6463
Véronique MathieuDepartment of Pharmacotherapy and Pharmaceutics, Chemistry and Biochemistry, Faculté de Pharmacie, Université Libre de Bruxelles, Brussels, Belgium.
Alexander KornienkoDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, Texas, 78666, USA.ORCID https://orcid.org/0000-0003-2041-7367

Funding

Acid-Sensitive Glioblastoma Prodrugs Derived from Ophiobolin AR15CA227680 · NCI · TEXAS STATE UNIVERSITY · PI KORNIENKO, ALEXANDER · 2019 to 2019
$462k
Alexander von Humboldt FoundationDenise M. Trauth Endowed Presidential Research ProfessorshipNational Research Foundation, South Africa AC21NCI NIH HHS R15 CA227680Stellenbosch UniversityUS National Institutes of Health CA227680-01 A1
6 · The paper itself

Abstract

We recently discovered that sphaeropsidin A (SphA), a fungal metabolite from Diplodia cupressi, overcomes apoptosis resistance in cancer cells by inducing cellular shrinkage by impairing regulatory volume increase. Previously, we prepared a pyrene-conjugated derivative of SphA by a cross-metathesis reaction involving the phytotoxin's C15,C16-alkene. This derivative's evaluation in a cancer cell panel revealed a significant increase in potency, with the IC

Indexed as

Antineoplastic AgentsDrug Screening Assays, AntitumorAscomycotaCell Line, TumorCell ProliferationDose-Response Relationship, DrugHumansMolecular StructurePyrenesStructure-Activity RelationshipAntineoplastic AgentsPyrenescancercross-metathesisDNA intercalationmutagenicpyrenesphaeropsidin A

Identifiers

PMID38895989
PMCPMC11645891

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.