Evidence map›Paper›PMID 38895979›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2024

Altered glucose kinetics occurs with aging: a new outlook on metabolic flexibility.

Casey C Curl, Robert G Leija, Jose A Arevalo, Adam D Osmond, Justin J Duong, Melvin J Huie, Umesh Masharani, Michael A Horning, George A Brooks

Abstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Resilience of the mitochondrial reticulum in aging.American journal of physiology. Endocrinology and metabolism · 2025
    Article
  8. Article
  9. Delayed and diminished postprandial lactate shuttling in healthy older men and women.American journal of physiology. Endocrinology and metabolism · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Casey C CurlExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States.
Robert G LeijaExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States.ORCID 0000-0002-7862-293X
Jose A ArevaloExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States.ORCID 0000-0002-1120-4960
Adam D OsmondExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States.
Justin J DuongExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States.
Melvin J HuieExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States.
Umesh MasharaniDepartment of Endocrinology, School of Medicine, University of California, San Francisco, California, United States.
Michael A HorningExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States.
George A BrooksExercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California, United States.ORCID 0000-0002-1389-1629

Funding

Aging Mitochondrial Fragmentation and Metabolic InflexibilityR01AG059715 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI BROOKS, GEORGE AUSTIN · 2018 to 2022
$3.0M
NIA NIH HHS R01 AG059715
6 · The paper itself

Abstract

Our purpose was to determine how age affects metabolic flexibility and underlying glucose kinetics in healthy young and older adults. Therefore, glucose and lactate tracers along with pulmonary gas exchange data were used to determine glucose kinetics and respiratory exchange ratios [RER = carbon dioxide production (V̇co

Indexed as

AgingBlood GlucoseGlucoseGlucose Tolerance TestAdultAgedAged, 80 and overFemaleGluconeogenesisHumansKineticsLactic AcidMaleMetabolic Clearance RateMiddle AgedOxygen ConsumptionBlood GlucoseGlucoseLactic Acideuglycemiafractional gluconeogenesisOGTTsextracer

Identifiers

PMID38895979
PMCPMC11427093

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.