Evidence map›Paper›PMID 38895950›Full record

ArticleActa physiologica (Oxford, England)2024

Greater physical fitness (

Emanuele R G Plini, Michael C Melnychuk, Ralph Andrews, Rory Boyle, Robert Whelan, Jeffrey S Spence, Sandra B Chapman, Ian H Robertson, Paul M Dockree

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta physiologica (Oxford, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Emanuele R G PliniDepartment of Psychology, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.ORCID 0000-0001-6889-5689
Michael C MelnychukDepartment of Psychology, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Ralph AndrewsDepartment of Psychology, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Rory BoyleDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
Robert WhelanDepartment of Psychology, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Jeffrey S SpenceCenter for BrainHealth, The University of Texas at Dallas, Dallas, Texas, USA.
Sandra B ChapmanCenter for BrainHealth, The University of Texas at Dallas, Dallas, Texas, USA.
Ian H RobertsonDepartment of Psychology, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Paul M DockreeDepartment of Psychology, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.

Funding

Brain & Cognitive Changes after Reasoning or Physical Training in Cognitively NorRC1AG035954 · NIA · UNIVERSITY OF TEXAS DALLAS · PI CHAPMAN, SANDRA BOND · 2009 to 2010
$1.0M
NIA NIH HHS RC1 AG035954Project founded by the Irish Research Council-Irish Research Council Laureate Consolidator Award (2018-23) IRCLA/2017/306 to Paul Dockree.the National Institutes of Health (RC1-AG035954)This work was also supported by ProApto which partly funded the study
6 · The paper itself

Abstract

aimPhysical activity (PA) is a key component for brain health and Reserve, and it is among the main dementia protective factors. However, the neurobiological mechanisms underpinning Reserve are not fully understood. In this regard, a noradrenergic (NA) theory of cognitive reserve (Robertson, 2013) has proposed that the upregulation of NA system might be a key factor for building reserve and resilience to neurodegeneration because of the neuroprotective role of NA across the brain. PA elicits an enhanced catecholamine response, in particular for NA. By increasing physical commitment, a greater amount of NA is synthetised in response to higher oxygen demand. More physically trained individuals show greater capabilities to carry oxygen resulting in greater

methodsWe hypothesized that greater

resultsAs hypothesized, greater

conclusionThis newly established link between

Indexed as

Locus CoeruleusNorepinephrinePhysical FitnessAgedExerciseFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedOxygen ConsumptionNorepinephrineagingbrain agelocus Coeruleus;neuroimagingneuromodulatorsvoxel‐based morphometry

Identifiers

PMID38895950
PMCPMC11250687

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.