Evidence map›Paper›PMID 38895475›Full record

ArticlebioRxiv : the preprint server for biology2024

Stick-slip unfolding favors self-association of expanded

Brett M O'Brien, Roumita Moulick, Gabriel Jiménez-Avalos, Nandakumar Rajasekaran, Christian M Kaiser, Sarah A Woodson

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Brett M O'BrienChemical Biology Interface Program, Johns Hopkins University, Baltimore, MD 21218 USA.
Roumita MoulickT. C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218 USA.
Gabriel Jiménez-AvalosT. C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218 USA.
Nandakumar RajasekaranDepartment of Biology, Johns Hopkins University, Baltimore, MD 21218 USA.
Christian M KaiserDepartment of Biology, Johns Hopkins University, Baltimore, MD 21218 USA.
Sarah A WoodsonChemical Biology Interface Program, Johns Hopkins University, Baltimore, MD 21218 USA.ORCID 0000-0003-0170-1987

Funding

The Chemistry-Biology Interface Program at Johns Hopkins UniversityT32GM080189 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ROKITA, STEVEN E · 2008 to 2022
$3.5M
Molecular Origins of Neurodegeneration through Force Detangling of Toxic RNAR21NS128701 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KAISER, CHRISTIAN, WOODSON, SARAH A. · 2023 to 2024
$442k
NIGMS NIH HHS T32 GM080189NINDS NIH HHS R21 NS128701
6 · The paper itself

Abstract

In Huntington's Disease (HD) and related disorders, expansion of CAG trinucleotide repeats produces a toxic gain of function in affected neurons. Expanded

Identifiers

PMID38895475
PMCPMC11185545

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.