Evidence map›Paper›PMID 38895461›Full record

ArticlebioRxiv : the preprint server for biology2024

A predominately pulmonary activation of complement in a mouse model of severe COVID-19.

Peter J Szachowicz, Christine Wohlford-Lenane, Cobey J Heinen, Shreya Ghimire, Biyun Xue, Timothy J Boly, Abhishek Verma, Leila MašinoviĆ, Jennifer R Bermick, Stanley Perlman and 5 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Peter J SzachowiczDepartment of Internal Medicine, The University of Iowa, Division of Pulmonary, Critical Care, and Occupational Medicine, Iowa City, IA, 52242.ORCID 0000-0003-1735-297X
Christine Wohlford-LenaneStead Family Department of Pediatrics, The University of Iowa, Iowa City, IA, 52242.
Cobey J HeinenMolecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, University of Iowa, USA.
Shreya GhimireDepartment of Internal Medicine, The University of Iowa, Division of Pulmonary, Critical Care, and Occupational Medicine, Iowa City, IA, 52242.ORCID 0000-0001-8975-7998
Biyun XueStead Family Department of Pediatrics, The University of Iowa, Iowa City, IA, 52242.
Timothy J BolyStead Family Department of Pediatrics, The University of Iowa, Iowa City, IA, 52242.ORCID 0000-0002-8892-8086
Abhishek VermaDepartment of Microbiology and Immunology, The University of Iowa, Iowa City, IA, 52242.
Leila MašinoviĆDepartment of Internal Medicine, The University of Iowa, Division of Pulmonary, Critical Care, and Occupational Medicine, Iowa City, IA, 52242.
Jennifer R BermickStead Family Department of Pediatrics, The University of Iowa, Iowa City, IA, 52242.ORCID 0000-0002-0245-946X
Stanley PerlmanStead Family Department of Pediatrics, The University of Iowa, Iowa City, IA, 52242.ORCID 0000-0003-4213-2354
David K MeyerholzDepartment of Pathology, The University of Iowa, Iowa City, IA, 52242.ORCID 0000-0003-1552-3253
Alejandro A PezzuloDepartment of Internal Medicine, The University of Iowa, Division of Pulmonary, Critical Care, and Occupational Medicine, Iowa City, IA, 52242.ORCID 0000-0001-7544-5109
Yuzhou ZhangMolecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, University of Iowa, USA.
Richard J H SmithMolecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, University of Iowa, USA.
Paul B McCrayStead Family Department of Pediatrics, The University of Iowa, Iowa City, IA, 52242.ORCID 0000-0002-4067-577X

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
SARS-CoV Proteins in Heterologous Viral InfectionP01AI060699 · NIAID · UNIVERSITY OF IOWA · PI PERLMAN, STANLEY · 2004 to 2021
$21.5M
Epigenetic mechanisms of inflammatory memory propagation in human airway epitheliaR01HL163024 · NHLBI · UNIVERSITY OF IOWA · PI Alejandro Antonio Pezzulo · 2022 to 2026
$2.8M
NHLBI NIH HHS R01 HL163024NIAID NIH HHS P01 AI060699NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

Evidence from in vitro studies and observational human disease data suggest the complement system plays a significant role in SARS-CoV-2 pathogenesis, although how complement dysregulation develops in patients with severe COVID-19 is unknown. Here, using a mouse-adapted SARS-CoV-2 virus (SARS2-N501Y

Indexed as

complementCOVID-19inflammationpulmonarySARS-CoV-2

Identifiers

PMID38895461
PMCPMC11185570

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.