Evidence map›Paper›PMID 38895441›Full record

ArticlebioRxiv : the preprint server for biology2024

Natural variation in protein kinase D modifies alcohol sensitivity in

Benjamin L Clites, Brooke Frohock, Emily J Koury, Erik C Andersen, Jonathan T Pierce

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Benjamin L ClitesWaggoner Center for Alcohol & Addiction Research, Center for Learning and Memory, Department of Neuroscience, University of Texas at Austin, Austin TX.
Brooke FrohockWaggoner Center for Alcohol & Addiction Research, Center for Learning and Memory, Department of Neuroscience, University of Texas at Austin, Austin TX.
Emily J KouryDepartment of Biology, Johns Hopkins University, Baltimore MD.
Erik C AndersenDepartment of Biology, Johns Hopkins University, Baltimore MD.
Jonathan T PierceWaggoner Center for Alcohol & Addiction Research, Center for Learning and Memory, Department of Neuroscience, University of Texas at Austin, Austin TX.

Funding

A screen for peptides that alter BK channel-mediated alcohol intoxicationR01AA020992 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI ALDRICH, RICHARD, MIHIC, S JOHN · 2012 to 2016
$2.0M
Synergistic patterned neurodegeneration by APP and APOE4RF1AG057355 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI PIERCE, JONATHAN THOMAS · 2017 to 2017
$1.9M
High-throughput interrogation of autism risk genes: from molecules to behaviorR01MH133243 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI PIERCE, JONATHAN THOMAS · 2023 to 2025
$1.1M
Systematic functional study of 21st chromosome ortholog overexpression in C. elegansR21OD032463 · OD · UNIVERSITY OF TEXAS AT AUSTIN · PI PIERCE, JONATHAN THOMAS · 2022 to 2023
$574k
NIAAA NIH HHS R01 AA020992NIA NIH HHS RF1 AG057355NIH HHS R21 OD032463NIMH NIH HHS R01 MH133243
6 · The paper itself

Abstract

Differences in naïve alcohol sensitivity between individuals are a strong predictor of later life alcohol use disorders (AUD). However, the genetic bases for alcohol sensitivity (beyond ethanol metabolism) and pharmacological approaches to modulate alcohol sensitivity remain poorly understood. We used a high-throughput behavioral screen to measure acute behavioral sensitivity to alcohol, a model of intoxication, in a genetically diverse set of over 150 wild strains of the nematode

Indexed as

alcohol sensitivityGWASprotein kinase D

Identifiers

PMID38895441
PMCPMC11185769

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.