Evidence map›Paper›PMID 38895426›Full record

ArticlebioRxiv : the preprint server for biology2024

Comparative connectomics of the descending and ascending neurons of the

Tomke Stürner, Paul Brooks, Laia Serratosa Capdevila, Billy J Morris, Alexandre Javier, Siqi Fang, Marina Gkantia, Sebastian Cachero, Isabella R Beckett, Andrew S Champion and 26 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Tomke StürnerNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0003-4054-0784
Paul BrooksDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.ORCID 0000-0001-9201-1062
Laia Serratosa CapdevilaDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.ORCID 0000-0001-9167-0285
Billy J MorrisDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.ORCID 0000-0003-3412-1794
Alexandre JavierDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-7942-6068
Siqi FangDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-7979-5170
Marina GkantiaDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-3142-6384
Sebastian CacheroNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0002-6828-1211
Isabella R BeckettNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0009-0001-3527-6782
Andrew S ChampionDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-6883-0081
Ilina MoitraDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-5801-1170
Alana RichardsDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.
Finja KlemmGenetics Department, Leipzig University, Leipzig, Germany.
Leonie KugelGenetics Department, Leipzig University, Leipzig, Germany.
Shigehiro NamikiResearch Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan.ORCID 0000-0003-1559-799X
Han S J CheongJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.ORCID 0000-0001-5233-3438
Julie KovalyakJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.ORCID 0000-0001-7864-7734
Emily TenshawJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.ORCID 0000-0003-3291-1733
Ruchi ParekhJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.ORCID 0000-0002-8060-2807
Philipp SchlegelDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-5633-1314
Jasper S PhelpsDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-8033-258X
Brandon MarkDepartment of Physiology and Biophysics, University of Washington, Seattle, WA, USA.ORCID 0000-0002-2607-3756
Sven DorkenwaldPrinceton Neuroscience Institute, Princeton University, Princeton, USA.ORCID 0000-0003-2352-319X
Alexander S BatesNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0002-1195-0445
Arie MatsliahPrinceton Neuroscience Institute, Princeton University, Princeton, USA.ORCID 0009-0001-4490-2028
Szi-Chieh YuPrinceton Neuroscience Institute, Princeton University, Princeton, USA.ORCID 0009-0001-9684-0156
Claire E McKellarPrinceton Neuroscience Institute, Princeton University, Princeton, USA.ORCID 0000-0002-3580-7336
Amy SterlingPrinceton Neuroscience Institute, Princeton University, Princeton, USA.ORCID 0000-0002-4961-3954
Sebastian SeungPrinceton Neuroscience Institute, Princeton University, Princeton, USA.ORCID 0000-0002-8591-6733
Mala MurthyComputer Science Department, Princeton University, USA.ORCID 0000-0003-3063-3389
John TuthillDepartment of Physiology and Biophysics, University of Washington, Seattle, WA, USA.ORCID 0000-0002-5689-5806
Wei-Chung A LeeDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-4618-295X
Gwyneth M CardJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.ORCID 0000-0002-7679-3639
Marta CostaDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.ORCID 0000-0001-5948-3092
Gregory S X E JefferisNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0002-0587-9355
Katharina EichlerDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.ORCID 0000-0002-7833-8621

Funding

Accelerating connectomic proofreading for larger brains and multiple individualsRF1MH129268 · NIMH · PRINCETON UNIVERSITY · PI MURTHY, MALA · 2022 to 2022
$2.1M
Automating whole brain connectomics: development, validation, and application of an open toolkitRF1MH120679 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BOCK, DAVI · 2019 to 2019
$1.9M
NIMH NIH HHS RF1 MH120679NIMH NIH HHS RF1 MH129268Wellcome Trust
6 · The paper itself

Abstract

In most complex nervous systems there is a clear anatomical separation between the nerve cord, which contains most of the final motor outputs necessary for behaviour, and the brain. In insects, the neck connective is both a physical and information bottleneck connecting the brain and the ventral nerve cord (VNC, spinal cord analogue) and comprises diverse populations of descending (DN), ascending (AN) and sensory ascending neurons, which are crucial for sensorimotor signalling and control. Integrating three separate EM datasets, we now provide a complete connectomic description of the ascending and descending neurons of the female nervous system of

Identifiers

PMID38895426
PMCPMC11185702

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.