Evidence map›Paper›PMID 38895412›Full record

ArticlebioRxiv : the preprint server for biology2024

Phage detection by a bacterial NLR-related protein is mediated by DnaJ.

Amy N Conte, Madison E Ruchel, Samantha M Ridgeway, Emily M Kibby, Toni A Nagy, Aaron T Whiteley

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Amy N ConteDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.ORCID 0000-0002-4723-4221
Madison E RuchelDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.
Samantha M RidgewayDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.
Emily M KibbyDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.ORCID 0000-0002-5506-4576
Toni A NagyDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.ORCID 0000-0002-2739-3540
Aaron T WhiteleyDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.ORCID 0000-0002-0075-7519

Funding

TRAINING IN SIGNAL TRANSDUCTION &CELL CYCLE REGULATIONT32GM008759 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI AHN, NATALIE G. · 2000 to 2020
$5.9M
Predoctoral Training Program in Signaling and Cellular Regulation INCLUDE Down Syndrome SupplementT32GM142607 · NIGMS · UNIVERSITY OF COLORADO · PI Sabrina Leigh Spencer, Tin Tin Su · 2021 to 2026
$3.6M
Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed)DP2AT012346 · NCCIH · UNIVERSITY OF COLORADO · PI WHITELEY, AARON THOMAS · 2022 to 2025
$2.4M
Bridges to the Baccalaureate Research Training Program at University of Colorado BoulderT34GM142601 · NIGMS · UNIVERSITY OF COLORADO · PI Martha Caron, Deborah Craven · 2023 to 2026
$1.1M
Q Exactive HF Nanoflow LC Mass Spectrometry SystemS10OD025267 · OD · UNIVERSITY OF COLORADO · PI AHN, NATALIE G. · 2018 to 2018
$600k
NCCIH NIH HHS DP2 AT012346NIGMS NIH HHS T32 GM008759NIGMS NIH HHS T32 GM142607NIGMS NIH HHS T34 GM142601NIH HHS S10 OD025267
6 · The paper itself

Abstract

Bacteria encode a wide range of antiphage systems and a subset of these proteins are homologous to components of the human innate immune system. Mammalian nucleotide-binding and leucine-rich repeat containing proteins (NLRs) and bacterial NLR-related proteins use a central NACHT domain to link detection of infection with initiation of an antimicrobial response. Bacterial NACHT proteins provide defense against both DNA and RNA phages. Here we determine the mechanism of RNA phage detection by the bacterial NLR-related protein bNACHT25 in

Indexed as

antiphagebacteriabacteriophagebNACHTcapsidchaperonecoat proteinDnaJinnate immunityMS2NACHTNLRphage

Identifiers

PMID38895412
PMCPMC11185742

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.