Evidence map›Paper›PMID 38895393›Full record

ArticlebioRxiv : the preprint server for biology2024

Cell-type-specific cholinergic control of granular retrosplenial cortex with implications for angular velocity coding across brain states.

Izabela Jedrasiak-Cape, Chloe Rybicki-Kler, Isla Brooks, Megha Ghosh, Ellen K W Brennan, Sameer Kailasa, Tyler G Ekins, Alan Rupp, Omar J Ahmed

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Izabela Jedrasiak-CapeDept. of Psychology, University of Michigan, Ann Arbor, MI 48109.
Chloe Rybicki-KlerDept. of Psychology, University of Michigan, Ann Arbor, MI 48109.
Isla BrooksDept. of Psychology, University of Michigan, Ann Arbor, MI 48109.
Megha GhoshDept. of Psychology, University of Michigan, Ann Arbor, MI 48109.
Ellen K W BrennanDept. of Psychology, University of Michigan, Ann Arbor, MI 48109.
Sameer KailasaDept. of Mathematics, University of Michigan, Ann Arbor, MI 48109.
Tyler G EkinsDept. of Psychology, University of Michigan, Ann Arbor, MI 48109.
Alan RuppDept. of Internal Medicine, University of Michigan, Ann Arbor, MI 48109.
Omar J AhmedDept. of Psychology, University of Michigan, Ann Arbor, MI 48109.

Funding

Udall Catalyst Research Project: Retrosplenial Cholinergic and Attentional-Motor Integration DysfunctionP50NS123067 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALBIN, ROGER L · 2021 to 2025
$11.6M
Sensory Mechanisms and Disorders - Administrative SupplementT32DC000011 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Michael Thomas Roberts · 1989 to 2026
$9.5M
POSTDOCTORAL TRAINING IN THE BIOLOGY OF DRUG ABUSET32DA007268 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TRAYNOR, JOHN R. · 1991 to 2021
$6.7M
Early Stage Training in the NeurosciencesT32NS076401 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Carol Fuzeti Elias, LESLIE S. SATIN · 2011 to 2026
$3.1M
Enabling precise cell-type-specific dissection of orientation and memory circuits in retrosplenial cortexR34NS127101 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AHMED, OMAR JAMIL · 2022 to 2022
$679k
The Retrosplenial Gate Hypothesis for Anterior Thalamic Stimulation in Temporal Lobe Epilepsy (Diversity Supplement)R21NS121745 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AHMED, OMAR JAMIL · 2021 to 2021
$514k
Cell-type-specific dissection of retrosplenial circuits in preclinical models of Alzheimer's diseaseF31AG087629 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RYBICKI-KLER, CHLOE ISABELLA · 2024 to 2025
$86k
NIA NIH HHS F31 AG087629NIDA NIH HHS T32 DA007268NIDCD NIH HHS T32 DC000011NINDS NIH HHS P50 NS123067NINDS NIH HHS R21 NS121745NINDS NIH HHS R34 NS127101NINDS NIH HHS T32 NS076401
6 · The paper itself

Abstract

Cholinergic receptor activation enables the persistent firing of cortical pyramidal neurons, providing a key cellular basis for theories of spatial navigation involving working memory, path integration, and head direction encoding. The granular retrosplenial cortex (RSG) is important for spatially-guided behaviors, but how acetylcholine impacts RSG neurons is unknown. Here, we show that a transcriptomically, morphologically, and biophysically distinct RSG cell-type - the low-rheobase (LR) neuron - has a very distinct expression profile of cholinergic muscarinic receptors compared to all other neighboring excitatory neuronal subtypes. LR neurons do not fire persistently in response to cholinergic agonists, in stark contrast to all other principal neuronal subtypes examined within the RSG and across midline cortex. This lack of persistence allows LR neuron models to rapidly compute angular head velocity (AHV), independent of cholinergic changes seen during navigation. Thus, LR neurons can consistently compute AHV across brain states, highlighting the specialized RSG neural codes supporting navigation.

Identifiers

PMID38895393
PMCPMC11185600

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.