Evidence map›Paper›PMID 38895384›Full record

ArticlebioRxiv : the preprint server for biology2024

BMAL1-HIF2α heterodimers contribute to ccRCC.

Rebecca M Mello, Diego Gomez Ceballos, Colby R Sandate, Daniel Agudelo, Celine Jouffe, Nina Henriette Uhlenhaut, Nicolas H Thomä, M Celeste Simon, Katja A Lamia

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rebecca M MelloDepartment of Molecular and Cellular Biology, Scripps Research Institute, La Jolla, CA, 92037, USA.
Diego Gomez CeballosDepartment of Molecular and Cellular Biology, Scripps Research Institute, La Jolla, CA, 92037, USA.
Colby R SandateFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Daniel AgudeloInstitute for Diabetes and Endocrinology (IDE), Helmholtz Munich, Ingolstaedter Landstr. 1, 85764, Neuherberg, Germany.
Celine JouffeInstitute for Diabetes and Endocrinology (IDE), Helmholtz Munich, Ingolstaedter Landstr. 1, 85764, Neuherberg, Germany.
Nina Henriette UhlenhautInstitute for Diabetes and Endocrinology (IDE), Helmholtz Munich, Ingolstaedter Landstr. 1, 85764, Neuherberg, Germany.
Nicolas H ThomäFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
M Celeste SimonAbramson Family Cancer Research Institute, Perelman School of Medicine; Philadelphia, Pennsylvania 19104, USA.
Katja A LamiaDepartment of Molecular and Cellular Biology, Scripps Research Institute, La Jolla, CA, 92037, USA.ORCID 0000-0001-9533-0499

Funding

Impacting Cell Growth through altered circadian proteolysisR01CA211187 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI Katja A Lamia · 2017 to 2026
$4.6M
Establishing a mechanistic basis for enhanced tumorigenesis under chronic circadian disruptionR01CA271500 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI Katja A Lamia · 2023 to 2026
$2.4M
NCI NIH HHS R01 CA211187NCI NIH HHS R01 CA271500
6 · The paper itself

Abstract

Circadian disruption enhances cancer risk, and many tumors exhibit disordered circadian gene expression. We show rhythmic gene expression is unexpectedly robust in clear cell renal cell carcinoma (ccRCC). Furthermore, the clock gene

Identifiers

PMID38895384
PMCPMC11185709

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.