Evidence map›Paper›PMID 38895362›Full record

ArticlebioRxiv : the preprint server for biology2024

APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology.

Kristine M Tran, Nellie Kwang, Angela Gomez-Arboledas, Shimako Kawauchi, Cassandra Mar, Donna Chao, Celia Da Cunha, Shuling Wang, Sherilyn Collins, Amber Walker and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Kristine M TranDepartment of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.ORCID 0000-0002-4444-7221
Nellie KwangDepartment of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.
Angela Gomez-ArboledasInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA.
Shimako KawauchiInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA.
Cassandra MarDepartment of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.
Donna ChaoDepartment of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.
Celia Da CunhaInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA.
Shuling WangTransgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, CA 92697, USA.
Sherilyn CollinsTransgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, CA 92697, USA.
Amber WalkerTransgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, CA 92697, USA.
Kai-Xuan ShiTransgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, CA 92697, USA.
Joshua A AlcantaraTransgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, CA 92697, USA.
Jonathan NeumannTransgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, CA 92697, USA.
Andrea J TennerDepartment of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.
Frank M LaFerlaDepartment of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.
Lindsay A HohsfieldDepartment of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.
Vivek SwarupDepartment of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.
Grant R MacGregorTransgenic Mouse Facility, ULAR, Office of Research, University of California, Irvine, CA 92697, USA.
Kim N GreenDepartment of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.

Funding

UC Irvine MODEL-ADU54AG054349 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green, FRANK M LAFERLA · 2017 to 2026
$71.9M
Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Role of Disease-Associated Microglia in Alzheimer's diseaseR01AG081599 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green · 2024 to 2026
$2.3M
Summer Medical student Aging and Alzheimer disease Research Training (SMAART) programT35AG076424 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Joshua Grill, Elizabeth Head · 2022 to 2026
$361k
Determining the mechanisms of the protective APOE3ch variant on Alzheimer's Disease pathologiesF31AG084190 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI TRAN, KRISTINE MINH · 2023 to 2024
$89k
NCI NIH HHS P30 CA062203NIA NIH HHS F31 AG084190NIA NIH HHS R01 AG081599NIA NIH HHS T35 AG076424NIA NIH HHS U54 AG054349
6 · The paper itself

Abstract

Background: Apolipoprotein E ε4 (APOE4) is the strongest genetic risk factor for late-onset Alzheimer's disease (LOAD). A recent case report identified a rare variant in APOE, APOE3-R136S (Christchurch), proposed to confer resistance to autosomal dominant Alzheimer's Disease (AD). However, it remains unclear whether and how this variant exerts its protective effects. Methods: We introduced the R136S variant into mouse Results: In 5xFAD mice, Conclusions: These findings highlight the ability of the

Indexed as

5xFADAmyloidAPOE ChristchurchDAMmicrogliaPS19resilienceTau

Identifiers

PMID38895362
PMCPMC11185750

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.