Evidence map›Paper›PMID 38895321›Full record

ArticlebioRxiv : the preprint server for biology2024

TLR4 deficiency does not alter glaucomatous progression in a mouse model of chronic glaucoma.

Chi Zhang, Marina Simón, Jeffrey M Harder, Haeyn Lim, Christa Montgomery, Qing Wang, Simon W M John

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Chi ZhangDepartment of Ophthalmology, Columbia University Irving Medical Center, New York, NY.
Marina SimónDepartment of Ophthalmology, Columbia University Irving Medical Center, New York, NY.
Jeffrey M HarderThe Jackson Laboratory, Bar Harbor, ME.
Haeyn LimDepartment of Ophthalmology, Columbia University Irving Medical Center, New York, NY.
Christa MontgomeryDepartment of Ophthalmology, Columbia University Irving Medical Center, New York, NY.
Qing WangDepartment of Ophthalmology, Columbia University Irving Medical Center, New York, NY.
Simon W M JohnDepartment of Ophthalmology, Columbia University Irving Medical Center, New York, NY.ORCID 0000-0002-4319-0356

Funding

Instrumentation, Fabrication, and Design CoreP30EY019007 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Xin Zhang · 2010 to 2026
$12.9M
Factors Determining Intraocular Pressure and Glaucoma SusceptibilityR01EY011721 · NEI · JACKSON LABORATORY · PI JOHN, SIMON W · 2002 to 2018
$12.4M
Cell Death Pathways in Glaucomatous NeurodegenerationR01EY018606 · NEI · UNIVERSITY OF ROCHESTER · PI JOHN, SIMON W, LIBBY, RICHARD T · 2008 to 2023
$5.8M
Does VECAD at Schlemm canal cell-junctions determine IOP and glaucoma risk?R01EY032062 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JOHN, SIMON W, KIZHATIL, KRISHNAKUMAR · 2021 to 2025
$3.5M
Models, mechanisms and treatment of LMX1B-induced glaucomaR01EY032507 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JOHN, SIMON W · 2021 to 2024
$2.3M
FACTORS DETERMINING INTRAOCULAR PRESSURER29EY011721 · NEI · JACKSON LABORATORY · PI JOHN, SIMON W · 1997 to 2001
$227k
NEI NIH HHS P30 EY019007NEI NIH HHS R01 EY011721NEI NIH HHS R01 EY018606NEI NIH HHS R01 EY032062NEI NIH HHS R01 EY032507NEI NIH HHS R29 EY011721
6 · The paper itself

Abstract

Glaucoma is a leading cause of irreversible blindness worldwide. Toll-like receptor 4 (TLR4) is a pattern-recognition transmembrane receptor that induces neuroinflammatory processes in response to injury.

Identifiers

PMID38895321
PMCPMC11185798

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.