Evidence map›Paper›PMID 38895296›Full record

ArticlebioRxiv : the preprint server for biology2025

Loss of mitochondrial pyruvate transport initiates cardiac glycogen accumulation and heart failure.

Rachel C Weiss, Kelly D Pyles, Kevin Cho, Michelle Brennan, Jonathan S Fisher, Gary J Patti, Kyle S McCommis

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rachel C WeissEdward A. Doisy Department of Biochemistry & Molecular Biology, Saint Louis University School of Medicine.
Kelly D PylesEdward A. Doisy Department of Biochemistry & Molecular Biology, Saint Louis University School of Medicine.
Kevin ChoDepartments of Chemistry, Medicine, and Center for Mass Spectrometry and Metabolic Tracing, Washington University in St. Louis.ORCID 0000-0002-3041-3506
Michelle BrennanEdward A. Doisy Department of Biochemistry & Molecular Biology, Saint Louis University School of Medicine.
Jonathan S FisherDepartment of Biology, Saint Louis University.
Gary J PattiDepartments of Chemistry, Medicine, and Center for Mass Spectrometry and Metabolic Tracing, Washington University in St. Louis.
Kyle S McCommisEdward A. Doisy Department of Biochemistry & Molecular Biology, Saint Louis University School of Medicine.ORCID 0000-0003-2381-1589

Funding

Developing Metabolomic Technologies to Advance Environmental Exposure AnalysisR35ES028365 · NIEHS · WASHINGTON UNIVERSITY · PI PATTI, GARY J · 2017 to 2024
$5.9M
Importance and Regulation of Cardiac Mitochondrial Pyruvate TransportR00HL136658 · NHLBI · SAINT LOUIS UNIVERSITY · PI MCCOMMIS, KYLE S · 2019 to 2021
$747k
NHLBI NIH HHS R00 HL136658NIEHS NIH HHS R35 ES028365
6 · The paper itself

Abstract

Heart failure involves metabolic alterations including increased glycolysis despite unchanged or decreased glucose oxidation. The mitochondrial pyruvate carrier (MPC) regulates pyruvate entry into the mitochondrial matrix, and cardiac deletion of the MPC in mice causes heart failure. How MPC deletion results in heart failure is unknown. We performed targeted metabolomics and isotope tracing in wildtype (fl/fl) and cardiac-specific Mpc2-/- (CS-Mpc2-/-) hearts after in vivo injection of U-

Indexed as

heart failureketogenic dietmitochondriapyruvate

Identifiers

PMID38895296
PMCPMC11185624

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.