Evidence map›Paper›PMID 38895268›Full record

ArticlebioRxiv : the preprint server for biology2024

Glioma-derived M-CSF and IL-34 license M-MDSCs to suppress CD8

Gregory P Takacs, Julia S Garcia, Caitlyn A Hodges, Christian J Kreiger, Alexandra Sherman, Jeffrey K Harrison

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Gregory P TakacsDepartment of Pharmacology & Therapeutics, University of Florida College of Medicine, Gainesville, FL, 32610, United States.ORCID 0000-0001-8415-432X
Julia S GarciaDepartment of Pharmacology & Therapeutics, University of Florida College of Medicine, Gainesville, FL, 32610, United States.
Caitlyn A HodgesDepartment of Pharmacology & Therapeutics, University of Florida College of Medicine, Gainesville, FL, 32610, United States.
Christian J KreigerDepartment of Pharmacology & Therapeutics, University of Florida College of Medicine, Gainesville, FL, 32610, United States.
Alexandra ShermanDepartment of Pharmacology & Therapeutics, University of Florida College of Medicine, Gainesville, FL, 32610, United States.
Jeffrey K HarrisonDepartment of Pharmacology & Therapeutics, University of Florida College of Medicine, Gainesville, FL, 32610, United States.

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
Together: Transforming and Translating Discovery to Improve HealthTL1TR001428 · NCATS · UNIVERSITY OF FLORIDA · PI MCCORMACK, WAYNE T. · 2015 to 2023
$3.9M
Targeting CCR2-expressing myeloid cells to overcome immune checkpoint inhibitor resistance in gliomaR01NS108781 · NINDS · UNIVERSITY OF FLORIDA · PI HARRISON, JEFFREY K., MITCHELL, DUANE A. · 2018 to 2022
$1.9M
NCATS NIH HHS TL1 TR001428NCATS NIH HHS UL1 TR001427NINDS NIH HHS R01 NS108781
6 · The paper itself

Abstract

Glioblastoma (GBM) is the most common malignant primary brain tumor, resulting in poor survival despite aggressive therapies. GBM is characterized by a highly heterogeneous and immunosuppressive tumor microenvironment (TME) made up predominantly of infiltrating peripheral immune cells. One significant immune cell type that contributes to glioma immune evasion is a population of immunosuppressive cells, termed myeloid-derived suppressor cells (MDSCs). Previous studies suggest that a subset of myeloid cells, expressing monocytic (M)-MDSC markers and dual expression of chemokine receptors CCR2 and CX3CR1, utilize CCR2 to infiltrate the TME. This study evaluated the mechanism of CCR2

Indexed as

Chemokine ReceptorCSFGliomaImmuneMDSCMyeloidNOSSuppressionT cell

Identifiers

PMID38895268
PMCPMC11185662

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.