Evidence map›Paper›PMID 38895256›Full record

ArticlebioRxiv : the preprint server for biology2024

Development of highly multiplex targeted proteomics assays in biofluids using the Stellar mass spectrometer.

Deanna L Plubell, Philip M Remes, Christine C Wu, Cristina C Jacob, Gennifer E Merrihew, Chris Hsu, Nick Shulman, Brendan X MacLean, Lilian Heil, Kathleen Poston and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Deanna L PlubellDepartment of Genome Sciences, University of Washington, Seattle WA.ORCID 0000-0002-6580-8073
Philip M RemesThermo Fisher Scientific, San Jose, CA.ORCID 0000-0003-0567-4541
Christine C WuDepartment of Genome Sciences, University of Washington, Seattle WA.
Cristina C JacobThermo Fisher Scientific, San Jose, CA.
Gennifer E MerrihewDepartment of Genome Sciences, University of Washington, Seattle WA.ORCID 0000-0003-4903-0318
Chris HsuDepartment of Genome Sciences, University of Washington, Seattle WA.
Nick ShulmanDepartment of Genome Sciences, University of Washington, Seattle WA.
Brendan X MacLeanDepartment of Genome Sciences, University of Washington, Seattle WA.ORCID 0000-0002-9575-0255
Lilian HeilThermo Fisher Scientific, San Jose, CA.ORCID 0000-0002-9462-7327
Kathleen PostonDepartment of Neurology & Neurological Sciences, Stanford University, Palo Alto CA, USA.ORCID 0000-0003-3424-7143
Tom MontineDepartment of Pathology, Stanford University, Palo Alto CA, USA.
Michael J MacCossDepartment of Genome Sciences, University of Washington, Seattle WA.ORCID 0000-0003-1853-0256

Funding

University of Washington Nathan Shock Center of Excellence in the Basic Biology of AgingP30AG013280 · NIA · UNIVERSITY OF WASHINGTON · PI Maitreya J Dunham · 1995 to 2026
$27.1M
Project 4: Novel reagent development to enable molecular characterizationU19AG065156 · NIA · UNIVERSITY OF WASHINGTON · PI TIAN, LU · 2020 to 2024
$15.9M
Seattle Quant: A Resource for the Skyline Software EcosystemR24GM141156 · NIGMS · UNIVERSITY OF WASHINGTON · PI Michael MacCoss · 2021 to 2026
$6.7M
Quantifying proteins in plasma do democratize personalized medicine for patients with type 1 diabetesU01DK137097 · NIDDK · UNIVERSITY OF WASHINGTON · PI ANDREW N HOOFNAGLE, Michael MacCoss · 2023 to 2026
$3.4M
NIA NIH HHS P30 AG013280NIA NIH HHS U19 AG065156NIDDK NIH HHS U01 DK137097NIGMS NIH HHS R24 GM141156
6 · The paper itself

Abstract

The development of targeted assays that monitor biomedically relevant proteins is an important step in bridging discovery experiments to large scale clinical studies. Targeted assays are currently unable to scale to hundreds or thousands of targets. We demonstrate the generation of large-scale assays using a novel hybrid nominal mass instrument. The scale of these assays is achievable with the Stellar

Identifiers

PMID38895256
PMCPMC11185584

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.