Evidence map›Paper›PMID 38895199›Full record

ArticlebioRxiv : the preprint server for biology2024

Expansion of a bacterial operon during cancer treatment ameliorates drug toxicity.

Kai R Trepka, Wesley A Kidder, Than S Kyaw, Taylor Halsey, Christine A Olson, Edwin F Ortega, Cecilia Noecker, Vaibhav Upadhyay, Dalila Stanfield, Paige Steiding and 9 more

Registry-linked trialAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04054908 (Gut Microbiome and Oral Fluoropyrimidine Study in Patients With Colorectal Cancer), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04054908 completednot on this map

Gut Microbiome and Oral Fluoropyrimidine Study in Patients With Colorectal Cancer

TypeobservationalSponsorUniversity of California, San FranciscoRan2018 to 2022Enrolled50ConditionsGastrointestinal Microbiome, Neoplasm, Colorectal
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Kai R TrepkaDepartment of Microbiology and Immunology, University of California San Francisco; San Francisco, USA.ORCID 0000-0002-8672-6317
Wesley A KidderDepartment of Medicine, Division of Hematology and Oncology, University of California San Francisco; San Francisco, USA.
Than S KyawDepartment of Microbiology and Immunology, University of California San Francisco; San Francisco, USA.
Taylor HalseyDepartment of Microbiology and Immunology, University of California San Francisco; San Francisco, USA.
Christine A OlsonDepartment of Microbiology and Immunology, University of California San Francisco; San Francisco, USA.
Edwin F OrtegaDepartment of Microbiology and Immunology, University of California San Francisco; San Francisco, USA.
Cecilia NoeckerDepartment of Microbiology and Immunology, University of California San Francisco; San Francisco, USA.
Vaibhav UpadhyayDepartment of Microbiology and Immunology, University of California San Francisco; San Francisco, USA.
Dalila StanfieldUCSF Helen Diller Family Comprehensive Cancer Center; San Francisco, USA.
Paige SteidingUCSF Helen Diller Family Comprehensive Cancer Center; San Francisco, USA.
Benjamin G H GuthrieDepartment of Microbiology and Immunology, University of California San Francisco; San Francisco, USA.
Peter SpanogiannopoulosDepartment of Microbiology and Immunology, University of California San Francisco; San Francisco, USA.
Darren DumlaoDepartment of Gastroenterology, University of California San Francisco; San Francisco, USA.
Jessie A TurnbaughDepartment of Microbiology and Immunology, University of California San Francisco; San Francisco, USA.
Matthew D StachlerDepartment of Pathology, University of California San Francisco; San Francisco, USA.
Erin L Van BlariganUCSF Helen Diller Family Comprehensive Cancer Center; San Francisco, USA.
Alan P VenookDepartment of Medicine, Division of Hematology and Oncology, University of California San Francisco; San Francisco, USA.
Chloe E AtreyaDepartment of Medicine, Division of Hematology and Oncology, University of California San Francisco; San Francisco, USA.
Peter J TurnbaughDepartment of Microbiology and Immunology, University of California San Francisco; San Francisco, USA.ORCID 0000-0002-0888-2875

Funding

Medical Scientist Training Program (T32 NRSA Training Grant)T32GM141323 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Aimee Kao · 2021 to 2026
$10.5M
Predicting and preventing drug metabolism by the human gut microbiomeR01HL122593 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Peter James Turnbaugh · 2016 to 2026
$5.7M
Metabolism of cancer chemotherapeutics by the human gut microbiomeR01CA255116 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Peter James Turnbaugh · 2023 to 2026
$3.1M
Host-microbiome interactions shape the metabolic effects of ketogenic dietsR01DK114034 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TURNBAUGH, PETER JAMES · 2020 to 2024
$2.5M
Impact of the microbiome on chemotherapeutic outcomesF30CA257378 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KYAW, THAN SOE · 2021 to 2024
$190k
NCI NIH HHS F30 CA257378NCI NIH HHS R01 CA255116NHLBI NIH HHS R01 HL122593NIDDK NIH HHS R01 DK114034NIGMS NIH HHS T32 GM141323
6 · The paper itself

Abstract

Dose-limiting toxicities remain a major barrier to drug development and therapy, revealing the limited predictive power of human genetics. Herein, we demonstrate the utility of a more comprehensive approach to studying drug toxicity through longitudinal study of the human gut microbiome during colorectal cancer (CRC) treatment (NCT04054908) coupled to cell culture and mouse experiments. 16S rRNA gene sequencing revealed significant shifts in gut microbial community structure during oral fluoropyrimidine treatment across multiple patient cohorts, in mouse small and large intestinal contents, and in patient-derived

Identifiers

PMID38895199
PMCPMC11185696

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.