ArticleFrontiers in human neuroscience2024
Transcranial focused ultrasound to the posterior cingulate cortex modulates default mode network and subjective experience: an fMRI pilot study.
Article in Frontiers in human neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuromodulation effects of low-intensity transcranial focused ultrasound in human, a systematic review focusing on motor and sensory functions.Journal of neuroengineering and rehabilitation · 2025Pooled it
- Multi-focal ultrasound neuromodulation to the dorsal anterior cingulate cortex disrupts behavioural and neural pain processing.Nature communications · 2026Trial
- Trajectories of psychotic symptoms and fronto-parietal resting state functional connectivity MRI following an antipsychotic trial in medication-naïve first-episode psychosis patients.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Illuminating consciousness.Frontiers in psychology · 2026Review
- Spatially resolved EEG reveals theta-band network modulation following iTBS in aging and mild cognitive impairment.Frontiers in human neuroscience · 2026Article
- Alternating-contrast single-shot spiral MR-ARFI with model-based displacement map reconstruction.Magnetic resonance in medicine · 2026Article
- Role of thalamus in human conscious perception revealed by low-intensity focused ultrasound neuromodulation.Nature communications · 2025Article
- Decoding paradoxical BOLD responses to transcranial ultrasound stimulation with concurrent optoacoustic magnetic resonance imaging.Science advances · 2025Article
- Magnitude preparation-based MR-acoustic radiation force imaging.Magnetic resonance in medicine · 2025Article
- Role of Thalamus in Human Conscious Perception Revealed by Low-Intensity Focused Ultrasound Neuromodulation.bioRxiv : the preprint server for biology · 2025Article
- Neuromodulation with Ultrasound: Hypotheses on the Directionality of Effects and Community Resource.medRxiv : the preprint server for health sciences · 2025Article
- Mindfulness, cognition, and long-term meditators: Toward a science of advanced meditation.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- The effect of non-invasive transcranial focused ultrasound for depression on the default mode network: an open-label pilot trial.Frontiers in psychiatry · 2025Article
- Transcranial focused ultrasound targeting the default mode network for the treatment of depression.Frontiers in psychiatry · 2025Article
- Mindfulness-based neurofeedback: A systematic review of EEG and fMRI studies.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Novel NIBS in psychiatry: Unveiling TUS and TI for research and treatment.Brain and neuroscience advancesReview
- Meditation and neurofeedback: A systematic scoping review, synthesis, and future directions.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Transcranial focused ultrasound (TFUS) is an emerging neuromodulation tool for temporarily altering brain activity and probing network functioning. The effects of TFUS on the default mode network (DMN) are unknown. Objective: The study examined the effects of transcranial focused ultrasound (TFUS) on the functional connectivity of the default mode network (DMN), specifically by targeting the posterior cingulate cortex (PCC). Additionally, we investigated the subjective effects of TFUS on mood, mindfulness, and self-related processing. Methods: The study employed a randomized, single-blind design involving 30 healthy subjects. Participants were randomly assigned to either the active TFUS group or the sham TFUS group. Resting-state functional magnetic resonance imaging (rs-fMRI) scans were conducted before and after the TFUS application. To measure subjective effects, the Toronto Mindfulness Scale, the Visual Analog Mood Scale, and the Amsterdam Resting State Questionnaire were administered at baseline and 30 min after sonication. The Self Scale and an unstructured interview were also administered 30 min after sonication. Results: The active TFUS group exhibited significant reductions in functional connectivity along the midline of the DMN, while the sham TFUS group showed no changes. The active TFUS group demonstrated increased state mindfulness, reduced Global Vigor, and temporary alterations in the sense of ego, sense of time, and recollection of memories. The sham TFUS group showed an increase in state mindfulness, too, with no other subjective effects. Conclusions: TFUS targeted at the PCC can alter DMN connectivity and cause changes in subjective experience. These findings support the potential of TFUS to serve both as a research tool and as a potential therapeutic intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.