Evidence map›Paper›PMID 38895078›Full record

ArticleEJHaem2024

Clonally unrelated primary large B-cell lymphomas separated by over a decade involving the central nervous system and testicle: Possible predisposition to lymphomas of immune-privileged sites?

Giby V George, Diana G Aldowitz, Audrey N Jajosky, Danielle S Wallace, W Richard Burack, Jonathan W Friedberg, Siba El Hussein

Abstract readCase Reports
In one paragraph

Article in EJHaem, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Giby V GeorgeDepartment of Pathology and Laboratory Medicine University of Rochester Medical Center Rochester New York USA.ORCID https://orcid.org/0009-0007-9529-4564
Diana G AldowitzDepartment of Pathology and Laboratory Medicine University of Rochester Medical Center Rochester New York USA.
Audrey N JajoskyDepartment of Pathology and Laboratory Medicine University of Rochester Medical Center Rochester New York USA.
Danielle S WallaceWilmot Cancer Institute University of Rochester Medical Center Rochester New York USA.
W Richard BurackDepartment of Pathology and Laboratory Medicine University of Rochester Medical Center Rochester New York USA.
Jonathan W FriedbergWilmot Cancer Institute University of Rochester Medical Center Rochester New York USA.
Siba El HusseinDepartment of Pathology The University of Vermont Larner College of Medicine Burlington Vermont USA.ORCID https://orcid.org/0000-0002-1338-7107

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary large B-cell lymphomas of immune-privileged sites (IP-LBCLs) comprise LBCLs arising within "immune sanctuaries," including the central nervous system (CNS), vitreoretina, and testes. Although patients present with localized disease, the prognosis remains poor with high relapse rates, either at the originating site or within another immune-privileged site. Generally, in the presence of an antecedent IP-LBCL, subsequent LBCLs are expected to be clonally related. However, we present a primary CNS LBCL and later primary testicular LBCL in a middle-aged man, diagnosed over a decade apart, which proved to be clonally unrelated by targeted ultra-deep next-generation sequencing of the

Indexed as

clonalityprimary large B‐cell lymphomas of immune‐privileged sites

Identifiers

PMID38895078
PMCPMC11182395

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.