ArticleFrontiers in psychiatry2024
The brain in chronic insomnia and anxiety disorder: a combined structural and functional fMRI study.
Article in Frontiers in psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Functional brain alterations in anxious depression: Insights from whole-brain fMRI and meta-analysis.Dialogues in clinical neuroscience · 2026Pooled it
- Efficacy and safety of holographic scraping in insomnia: A systematic review and meta-analysis of randomized controlled trials.Medicine · 2026Pooled it
- Subtyping insomnia disorder with a population graph attention autoencoder: revealing two distinct biotypes.Frontiers in neuroscience · 2026Article
- Reduced gray matter in the prefrontal cortex and hippocampus: a potential neuroanatomical feature of insomnia comorbid with anxiety.Frontiers in psychiatry · 2026Article
- The incidence of postoperative sleep disturbance and its influencing factors in cancer patients.Journal of anesthesia and translational medicine · 2025Article
- Sleep quality and its determinants in patients with thyroid eye disease: a cross-sectional study.European journal of medical research · 2025Article
- Article
- Sleep Disturbances in PTSD: Insight from Clinical Studies.Missouri medicineReview
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Authors and funding
8 authors.
Funding
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Abstract
Background: Chronic insomnia disorder (CID) is usually associated with Generalized Anxiety Disorder (GAD), which may change brain structure and function. However, the possible brain markers, imaging characteristics, and pathophysiology are unknown. Objective: To look at the probable brain markers, imaging characteristics, and pathogenesis of CID in combination with GAD. Methods: A total of 57 patients with CID concomitant GAD and 57 healthy controls (HC) were enrolled. Voxel-based morphometry (VBM) and functional connectivity (FC) were utilized to measure gray matter volume (GMV) and functional changes. Correlation analysis was utilized to identify relationships between brain changes and clinical characteristics. Results: Patients had decreased GMV in the left cerebellum, right cerebellar peduncle, and left insula; increased FC between the left cerebellum and right angular gyrus, as well as between the left insula and anterior left cingulate gyrus; and decreased FC in several areas, including the left cerebellum with the middle left cingulate gyrus and the left insula with the left superior postcentral gyrus. These brain changes related to CID and GAD. These data could be used to identify relevant brain markers, imaging features, and to better understand the etiology. Conclusion: The intensity of insomnia in patients was strongly related to the severity of anxiety. The lower GMV in the cerebellum could be interpreted as an imaging characteristic of CID. Reduced GMV in the insula, as well as aberrant function in the cingulate gyrus and prefrontal lobe, may contribute to the pathophysiology of CID and GAD. Abnormal function in the postcentral gyrus and angular gyrus may be associated with patients' clinical complaints.
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