Evidence map›Paper›PMID 38895012›Full record

ArticleThe Neurohospitalist2024

Super Refractory Status Epilepticus Improved After Emergency Use of Ganaxolone: Case Report.

Jody Manners, Emily Jusuf, Gunjan Y Parikh, Maciej Gasior, Henrikas Vaitkevicius, Nicholas A Morris

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The Neurohospitalist, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jody MannersDepartment of Neurology, Program in Trauma, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-5875-3633
Emily JusufDepartment of Neurology, Program in Trauma, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0009-0004-8566-1293
Gunjan Y ParikhDepartment of Neurology, Program in Trauma, University of Maryland School of Medicine, Baltimore, MD, USA.
Maciej GasiorMarinus Pharmaceuticals, Radnor, PA, USA.
Henrikas VaitkeviciusMarinus Pharmaceuticals, Radnor, PA, USA.
Nicholas A MorrisDepartment of Neurology, Program in Trauma, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-1270-9805

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a case of a 34-year-old man with epilepsy who developed super refractory status epilepticus in the setting of COVID-19 pneumonia in whom aggressive therapy with multiple parenteral, enteral, and non-pharmacologic interventions were utilized without lasting improvement in clinical examination or electroencephalogram (EEG). The patient presented with multiple recurrences of electrographic status epilepticus throughout a prolonged hospital stay. Emergency use authorization was obtained for intravenous ganaxolone, a neuroactive steroid that is a potent modulator of both synaptic and extrasynaptic GABA

Indexed as

ganaxaloneseizurestatus epilepticus

Identifiers

PMID38895012
PMCPMC11181981

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.