Evidence map›Paper›PMID 38894950›Full record

ArticleBrain communications2024

Under pressure: the interplay of hypertension and white matter hyperintensities with cognition in chronic stroke aphasia.

Jade Hannan, Natalie Busby, Rebecca Roth, Janina Wilmskoetter, Roger Newman-Norlund, Chris Rorden, Leonardo Bonilha, Julius Fridriksson

Abstract read
In one paragraph

Article in Brain communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Digital Twin Model of Treatment Outcomes in Post-Stroke Aphasia.medRxiv : the preprint server for health sciences · 2026
    Article
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jade HannanDepartment of Communication Sciences and Disorders, University of South Carolina, Columbia, SC 29208, USA.ORCID https://orcid.org/0000-0003-2815-9905
Natalie BusbyDepartment of Communication Sciences and Disorders, University of South Carolina, Columbia, SC 29208, USA.ORCID https://orcid.org/0000-0001-7117-7899
Rebecca RothDepartment of Neurology, Emory University, Atlanta, GA 30322, USA.
Janina WilmskoetterDepartment of Health and Rehabilitation Sciences, Medical University of South Carolina, Charleston, SC 29425, USA.ORCID https://orcid.org/0000-0002-1083-7301
Roger Newman-NorlundDepartment of Psychology, University of South Carolina, Columbia, SC 29208, USA.
Chris RordenDepartment of Psychology, University of South Carolina, Columbia, SC 29208, USA.ORCID https://orcid.org/0000-0002-7554-6142
Leonardo BonilhaDepartment of Pharmacology, Physiology, and Neuroscience, University of South Carolina School of Medicine, Columbia, SC 29209, USA.
Julius FridrikssonDepartment of Communication Sciences and Disorders, University of South Carolina, Columbia, SC 29208, USA.

Funding

Telerehab for Aphasia (TERRA)P50DC014664 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FRIDRIKSSON, JULIUS · 2016 to 2025
$25.0M
Extending ezBIDS, NiiVue and dcm2niix for user-friendly cloud-based integration and visualizationRF1MH133701 · NIMH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI RORDEN, CHRISTOPHER · 2023 to 2023
$2.0M
NIDCD NIH HHS P50 DC014664NIMH NIH HHS RF1 MH133701
6 · The paper itself

Abstract

While converging research suggests that increased white matter hyperintensity load is associated with poorer cognition, and the presence of hypertension is associated with increased white matter hyperintensity load, the relationship among hypertension, cognition and white matter hyperintensities is not well understood. We sought to determine the effect of white matter hyperintensity burden on the relationship between hypertension and cognition in individuals with post-stroke aphasia, with the hypothesis that white matter hyperintensity load moderates the relationship between history of hypertension and cognitive function. Health history, Fazekas scores for white matter hyperintensities and Wechsler Adult Intelligence Scale Matrix Reasoning subtest scores for 79 people with aphasia collected as part of the Predicting Outcomes of Language Rehabilitation study at the Center for the Study of Aphasia Recovery at the University of South Carolina and the Medical University of South Carolina were analysed retrospectively. We found that participants with a history of hypertension had increased deep white matter hyperintensity severity (

Indexed as

aphasiabrain healthcognitionhypertensionstroke

Identifiers

PMID38894950
PMCPMC11184349

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.