Evidence map›Paper›PMID 38894929›Full record

ArticleACS medicinal chemistry letters2024

Stepwise Nitric Oxide Release and Antibacterial Activity of a Nitric Oxide Photodonor Hosted within Cyclodextrin Branched Polymer Nanocarriers.

Tassia J Martins, Cristina Parisi, Juliana Guerra Pinto, Isabelle de Paula Ribeiro Brambilla, Milo Malanga, Juliana Ferreira-Strixino, Salvatore Sortino

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Article in ACS medicinal chemistry letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tassia J MartinsPhotoChemLab, Department of Drug Sciences, University of Catania, I-95125 Catania, Italy.
Cristina ParisiPhotoChemLab, Department of Drug Sciences, University of Catania, I-95125 Catania, Italy.
Juliana Guerra PintoLaboratory of Photobiology Applied to Health, Research and Development Institute, University of Vale do Paraíba, Urbanova I-2911, Brazil.
Isabelle de Paula Ribeiro BrambillaLaboratory of Photobiology Applied to Health, Research and Development Institute, University of Vale do Paraíba, Urbanova I-2911, Brazil.
Milo MalangaCarboHyde, I-1045 Budapest, Hungary.
Juliana Ferreira-StrixinoLaboratory of Photobiology Applied to Health, Research and Development Institute, University of Vale do Paraíba, Urbanova I-2911, Brazil.
Salvatore SortinoPhotoChemLab, Department of Drug Sciences, University of Catania, I-95125 Catania, Italy.ORCID https://orcid.org/0000-0002-2086-1276

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A hydrophobic nitric oxide (NO) photodonor integrating both nitroso and nitro functionalities within its chromophoric skeleton has been synthesized. Excitation of this compound with blue light triggers the release of two NO molecules from the nitroso and the nitro functionalities via a stepwise mechanism. Encapsulation of the NO photodonor within biocompatible neutral, cationic, and anionic β-cyclodextrin branched polymers as suitable carriers leads to supramolecular nanoassemblies, which exhibit the same nature of the photochemical processes but NO photorelease performances enhanced by about 1 order of magnitude when compared with the free guest. Antibacterial tests carried out with methicillin-resistant

Identifiers

PMID38894929
PMCPMC11181500

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.