ArticleGeneral psychiatry2024
Lower synaptic density and its association with cognitive dysfunction in patients with obsessive-compulsive disorder.
Article in General psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Temporal interference stimulation of the nucleus accumbens in obsessive-compulsive disorder.General psychiatry · 2026Article
- Effectiveness of Deep Brain Stimulation for Treatment-Resistant OCD: Systematic Review of Anatomical Targets and Meta-Analysis of Randomized and Non-Randomized Studies.Brain sciences · 2026Review
- Functional connectivity density alterations in obsessive-compulsive disorder are associated with neurotransmitter and genetic profiles.Translational psychiatry · 2026Article
- Rare Variants in Antisense Long Noncoding RNA-Protein-Coding Gene Overlap Regions Contribute to Obsessive-Compulsive Disorder.Biological psychiatry global open science · 2026Article
- Structural synaptogenesis superior to functional modulation in a pruning-based recurrent network model of OCD.Frontiers in computational neuroscience · 2026Article
- Brain morphological changes across behaviour spectrums in attention-deficit/hyperactivity disorder.General psychiatry · 2025Article
- Mendelian Randomization Study Supports Genetic Liability to Obsessive-Compulsive Disorder Associated With the Risk of Alzheimer's Disease.Brain and behavior · 2024Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Understanding synaptic alteration in obsessive-compulsive disorder (OCD) is crucial for elucidating its pathological mechanisms, but Aims: This study aimed to identify the synaptic density indicators in OCD and explore the relationship between cognitive dysfunction and synaptic density changes in OCD. Methods: This study enrolled 28 drug-naive adults with OCD aged 18-40 years and 16 healthy controls (HCs). Three-dimensional T1-weighted structural magnetic resonance imaging and Results: Compared with HCs, patients with OCD showed reduced synaptic density in regions of the cortico-striato-thalamo-cortical circuit such as the bilateral putamen, left caudate, left parahippocampal gyrus, left insula, left parahippocampal gyrus and left middle occipital lobe (voxel p<0.001, uncorrected, with cluster level above 50 contiguous voxels). The per cent conceptual-level responses of WCST were positively associated with the synaptic density reduction in the left middle occipital gyrus (R Conclusions: Adults with OCD demonstrated lower
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