Evidence map›Paper›PMID 38894703›Full record

ArticleFrontiers in cellular neuroscience2024

Region and layer-specific expression of GABA

Kirill Zavalin, Anjana Hassan, Yueli Zhang, Zain Khera, Andre H Lagrange

Abstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kirill Zavalin *Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN, United States.
Anjana Hassan *Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN, United States.
Yueli ZhangDepartment of Neurology, Vanderbilt University School of Medicine, Nashville, TN, United States.
Zain KheraDepartment of Neurology, Vanderbilt University School of Medicine, Nashville, TN, United States.
Andre H LagrangeDepartment of Neurology, Vanderbilt University School of Medicine, Nashville, TN, United States.

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
Program in NeurogenomicsT32MH065215 · NIMH · VANDERBILT UNIVERSITY · PI ROGER J COLBRAN · 2002 to 2026
$6.4M
NICHD NIH HHS P50 HD103537NIMH NIH HHS T32 MH065215
6 · The paper itself

Abstract

Introduction: γ-Aminobutyric acid (GABA) type A receptors (GABA Methods: We evaluated expression of α1-5, β2-3, γ2, and δ GABA Results: We found that embryonic cortex expresses mainly α3, α5, β3, and γ2, while expression of α1, α2, α4, β2, δ, and KCC2 begins at later points in development; however, many patterns of nuanced expression can be found in specific lamina, cortical regions, and cells and structures. Discussion: While the general pattern of expression of each subunit and KCC2 is similar to previous studies, we found a number of unique temporal, regional, and laminar patterns that were previously unknown. These findings provide much needed knowledge of the intricate developmental evolution in GABA

Indexed as

cortical developmentdevelopmental expression patternGABA-A receptorsGABAA subtypesimmunohistochemistry (IHC)potassium chloride co-transporter 2 (KCC2)Western blot (WB)

Identifiers

PMID38894703
PMCPMC11184147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.