Evidence map›Paper›PMID 38893603›Full record

ArticleDiagnostics (Basel, Switzerland)2024

Nationwide Real-World Data of Microsatellite Instability and/or Mismatch Repair Deficiency in Cancer: Prevalence and Testing Patterns.

Elena Fountzilas, Theofanis Papadopoulos, Eirini Papadopoulou, Cedric Gouedard, Helen P Kourea, Pantelis Constantoulakis, Christina Magkou, Maria Sfakianaki, Vassiliki Kotoula, Dimitra Bantouna and 20 more

Abstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Elena FountzilasDepartment of Medical Oncology, St. Lukes's Clinic, 55236 Thessaloniki, Greece.
Theofanis PapadopoulosMolecular Diagnostics Laboratory, KARYO Ltd., 54622 Thessaloniki, Greece.
Eirini PapadopoulouGenekor M.S.A., 15344 Athens, Greece.
Cedric GouedardBioPath Innovations SA, 15124 Athens, Greece.
Helen P KoureaDepartment of Pathology, University Hospital of Patras, 26504 Patras, Greece.ORCID 0000-0002-7600-6973
Pantelis ConstantoulakisGenotypos Science Labs M.S.A., 11525 Athens, Greece.ORCID 0000-0001-6121-6364
Christina MagkouDepartment of Pathology, Evangelismos Hospital, 10676 Athens, Greece.
Maria SfakianakiLaboratory of Translational Oncology, Medical School, University of Crete, 71410 Heraklion, Greece.
Vassiliki KotoulaDepartment of Pathology, School of Health Sciences, Faculty of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Dimitra BantounaDepartment of Pathology, University Hospital of Patras, 26504 Patras, Greece.ORCID 0000-0001-5079-6228
Georgia RaptouDepartment of Pathology, School of Health Sciences, Faculty of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Angelica A SaettaFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, 15772 Athens, Greece.ORCID 0000-0002-4862-3413
Georgia ChristopoulouGenotypos Science Labs M.S.A., 11525 Athens, Greece.
Dimitris HatzibougiasmicroDiagnostics LP, Private Surgical & Molecular Pathology Laboratory, 54622 Thessaloniki, Greece.ORCID 0000-0002-1435-2379
Electra Michalopoulou-ManoloutsioumicroDiagnostics LP, Private Surgical & Molecular Pathology Laboratory, 54622 Thessaloniki, Greece.
Eleni SiatraDepartment of Pathology, Henry Dunant Hospital, 11526 Athens, Greece.
Eleftherios EleftheriadisIstodierevnitiki S.A., 54622 Thessaloniki, Greece.
Evangelia KavouraPathology Department, IASO Women's Hospital, 15123 Athens, Greece.
Loukas KaklamanisPathology Department, Onassis Cardiac Surgery Center, 17674 Athens, Greece.
Antigoni SourlaDepartment of Pathology and Laboratory Medicine, Bioiatriki Laboratories, 11528 Athens, Greece.
George PapaxoinisSecond Department of Internal Medicine, Agios Savvas Cancer Hospital, 11522 Athens, Greece.
Kitty PavlakisPathology Department, IASO Women's Hospital, 15123 Athens, Greece.
Prodromos HytiroglouDepartment of Pathology, School of Health Sciences, Faculty of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Christina VourlakouDepartment of Pathology, Evangelismos Hospital, 10676 Athens, Greece.
Petroula Arapantoni-DadiotiDepartment of Pathology, Henry Dunant Hospital, 11526 Athens, Greece.
Samuel MurrayBioPath Innovations SA, 15124 Athens, Greece.
George NasioulasGenekor M.S.A., 15344 Athens, Greece.
Grigorios TimologosMolecular Diagnostics Laboratory, KARYO Ltd., 54622 Thessaloniki, Greece.
George FountzilasLaboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, 54006 Thessaloniki, Greece.ORCID 0000-0001-8045-2186
Zacharenia SaridakiFirst Oncology Department, Metropolitan Hospital, 18547 Piraeus, Greece.ORCID 0000-0003-2931-5797

Funding

Hellenic Society for Medical Oncology (HeSMO) NA
6 · The paper itself

Abstract

Determination of microsatellite instability (MSI)/mismatch repair (MMR) status in cancer has several clinical implications. Our aim was to integrate MSI/MMR status from patients tested in Greece to assess the prevalence of MSI-high (MSI-H)/deficient MMR (dMMR) per tumor type, testing patterns over time and concordance between MSI and MMR status. We retrospectively recorded MSI/MMR testing data of patients with diverse tumor types performed in pathology and molecular diagnostics laboratories across Greece. Overall, 18 of 22 pathology and/or molecular diagnostics laboratories accepted our invitation to participate. In the 18 laboratories located across the country, 7916 tumor samples were evaluated for MSI/MMR status. MSI/MMR testing significantly increased in patients with colorectal cancer (CRC) and other tumor types overtime (

Indexed as

biomarkerGreeceimmunotherapyMMRMSInationwidereal-world data

Identifiers

PMID38893603
PMCPMC11171982

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.