Evidence map›Paper›PMID 38893511›Full record

ReviewMolecules (Basel, Switzerland)2024

Decoding the κ Opioid Receptor (KOR): Advancements in Structural Understanding and Implications for Opioid Analgesic Development.

Zoe Li, Ruili Huang, Menghang Xia, Nancy Chang, Wenjing Guo, Jie Liu, Fan Dong, Bailang Liu, Ann Varghese, Aasma Aslam and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zoe LiNational Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
Ruili HuangNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA.
Menghang XiaNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA.
Nancy ChangCenter for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, USA.
Wenjing GuoNational Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
Jie LiuNational Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
Fan DongNational Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
Bailang LiuNational Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
Ann VargheseNational Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
Aasma AslamNational Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
Tucker A PattersonNational Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.
Huixiao HongNational Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-8087-3968

Funding

Toxicology in the 21st Century Program (Tox21) - Systems ToxicologyZIATR000038 · NCATS · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · PI XIA, MENGHANG · 2015 to 2025
$5.7M
Toxicology in the 21st Century Program (Tox21) - Computational ToxicologyZIATR000040 · NCATS · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · PI HUANG, RUILI · 2016 to 2025
$3.5M
6 · The paper itself

Abstract

The opioid crisis in the United States is a significant public health issue, with a nearly threefold increase in opioid-related fatalities between 1999 and 2014. In response to this crisis, society has made numerous efforts to mitigate its impact. Recent advancements in understanding the structural intricacies of the κ opioid receptor (KOR) have improved our knowledge of how opioids interact with their receptors, triggering downstream signaling pathways that lead to pain relief. This review concentrates on the KOR, offering crucial structural insights into the binding mechanisms of both agonists and antagonists to the receptor. Through comparative analysis of the atomic details of the binding site, distinct interactions specific to agonists and antagonists have been identified. These insights not only enhance our understanding of ligand binding mechanisms but also shed light on potential pathways for developing new opioid analgesics with an improved risk-benefit profile.

Indexed as

Analgesics, OpioidReceptors, Opioid, kappaAnimalsBinding SitesHumansLigandsNarcotic AntagonistsPainProtein BindingSignal TransductionStructure-Activity RelationshipAnalgesics, OpioidLigandsNarcotic AntagonistsReceptors, Opioid, kappaagonistantagonistbindingligandmechanismopioidreceptorstructure

Identifiers

PMID38893511
PMCPMC11173883

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.