In Vitro Investigations into the Potential Drug Interactions of Pseudoginsenoside DQ Mediated by Cytochrome P450 and Human Drug Transporters.

Zhuo Li, Cuizhu Wang, Jinping Liu, Pingya Li, Hao Feng

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Zhuo LiSchool of Pharmaceutical Sciences, Jilin University, 126 Xinmin Street, Changchun 130021, China.

Cuizhu WangSchool of Pharmaceutical Sciences, Jilin University, 126 Xinmin Street, Changchun 130021, China.ORCID 0000-0002-0694-4059

Jinping LiuSchool of Pharmaceutical Sciences, Jilin University, 126 Xinmin Street, Changchun 130021, China.ORCID 0000-0003-4020-879X

Pingya LiSchool of Pharmaceutical Sciences, Jilin University, 126 Xinmin Street, Changchun 130021, China.

Hao FengDepartment of Human Anatomy, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun 130021, China.

Funding

Jilin Provincial Department of Science and Technology 20220204025YY

6 · The paper itself

Abstract

Pseudoginsenoside DQ (PDQ), an ocotillol-type ginsenoside, is synthesized with protopanaxadiol through oxidative cyclization. PDQ exhibits good anti-arrhythmia activity. However, the inhibitory effect of PDQ on the cytochrome 450 (CYP450) enzymes and major drug transporters is still unclear. Inhibition of CYP450 and drug transporters may affect the efficacy of the drugs being used together with PDQ. These potential drug-drug interactions (DDIs) are essential for the clinical usage of drugs. In this study, we investigated the inhibitory effect of PDQ on seven CYP450 enzymes and seven drug transporters with in vitro models. PDQ has a significant inhibitory effect on CYP2C19 and P-glycoprotein (P-gp) with a half-inhibitory concentration (IC

Indexed as

Cytochrome P-450 Enzyme SystemDrug InteractionsGinsenosidesATP Binding Cassette Transporter, Subfamily G, Member 2Cytochrome P-450 CYP2C19Cytochrome P-450 CYP3ACytochrome P-450 Enzyme InhibitorsHumansNeoplasm ProteinsABCG2 protein, humanATP Binding Cassette Transporter, Subfamily G, Member 2Cytochrome P-450 CYP2C19Cytochrome P-450 CYP3ACytochrome P-450 Enzyme InhibitorsCytochrome P-450 Enzyme SystemGinsenosidesNeoplasm Proteinscytochrome P450drug–drug interactions (DDIs)drug transporterspseudoginsenoside DQ

Identifiers

PMID38893358

DOI10.3390/molecules29112482

PMCPMC11173382

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.