Comparison of HPLC, HPTLC, and In Silico Lipophilicity Parameters Determined for 5-Heterocyclic 2-(2,4-Dihydroxyphenyl)-1,3,4-thiadiazoles.

Beata Paw, Rafał Śliwa, Łukasz Komsta, Bogusław Senczyna, Monika Karpińska, Joanna Matysiak

Abstract readComparative Study

In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Use of TLC and Computational Methods to Determine Lipophilicity Parameters of Selected Neuroleptics: Comparison of Experimental and Theoretical Studies.Pharmaceuticals (Basel, Switzerland) · 2025
Article

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5 · Who and what money

Authors and funding

6 authors.

Beata PawDepartment of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland.ORCID 0000-0002-8364-7680

Rafał ŚliwaDepartment of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland.ORCID 0000-0001-7855-8328

Łukasz KomstaDepartment of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland.ORCID 0000-0003-2261-2692

Bogusław SenczynaDepartment of Chemistry, University of Life Sciences in Lublin, Akademicka 15, 20-950 Lublin, Poland.

Monika KarpińskaŁukasiewicz Research Network-Institute of Industrial Organic Chemistry, Annopol 6, 03-236 Warsaw, Poland.

Joanna MatysiakDepartment of Chemistry, University of Life Sciences in Lublin, Akademicka 15, 20-950 Lublin, Poland.ORCID 0000-0002-0363-4450

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 5-heterocyclic 2-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles were obtained as potential biologically active compounds. Lipophilicity is one of the most important physicochemical properties of compounds and was already taken into account during the drug candidates design and development. The lipophilicity of compounds was determined using the computational (log P) and chromatography (log k

Indexed as

Hydrophobic and Hydrophilic InteractionsThiadiazolesChromatography, High Pressure LiquidChromatography, Reverse-PhaseChromatography, Thin LayerComputer Simulation1,3,4-thiadiazoleThiadiazolesliquid chromatographylog kwlog PPCARMwthiadiazoles

Identifiers

PMID38893351

DOI10.3390/molecules29112478

PMCPMC11173846

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