Evidence map›Paper›PMID 38893308›Full record

ArticleMolecules (Basel, Switzerland)2024

The Programmable Catalytic Core of 8-17 DNAzymes.

Fumei Zhang, Weiguo Shi, Lei Guo, Shihui Liu, Junlin He

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fumei ZhangSchool of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China.
Weiguo ShiBeijing Institute of Pharmacology and Toxicology, Taiping 27, Beijing 100850, China.
Lei GuoBeijing Institute of Pharmacology and Toxicology, Taiping 27, Beijing 100850, China.ORCID 0000-0003-4780-712X
Shihui LiuSchool of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China.
Junlin HeBeijing Institute of Pharmacology and Toxicology, Taiping 27, Beijing 100850, China.

Funding

the National Natural Science Foundation of China 21572268
6 · The paper itself

Abstract

8-17 DNAzymes (8-17, 17E, Mg5, and 17EV1) are in vitro-selected catalytic DNA molecules that are capable of cleaving complementary RNAs. The conserved residues in their similar catalytic cores, together with the metal ions, were suggested to contribute to the catalytic reaction. Based on the contribution of the less conserved residues in the bulge loop residues (W

Indexed as

DNA, CatalyticBase SequenceCatalysisCatalytic DomainHydrogen-Ion ConcentrationMetalsNucleic Acid ConformationDNA, CatalyticMetalscatalytic coreDNAzymemetal ion dependence

Identifiers

PMID38893308
PMCPMC11173380

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.