Evidence map›Paper›PMID 38893276›Full record

ArticleCancers2024

Non-Syndromic and Syndromic Defects in Children with Extracranial Germ Cell Tumors: Data of 2610 Children Registered with the German MAKEI 96/MAHO 98 Registry Compared to the General Population.

Judit H Schultewolter, Anke Rissmann, Dietrich von Schweinitz, Michael Frühwald, Claudia Blattmann, Lars Fischer, Björn Sönke Lange, Rüdiger Wessalowski, Birgit Fröhlich, Wolfgang Behnisch and 14 more

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Judit H SchultewolterUniversity Bonn, Venusberg Campus 1, 53127 Bonn, Germany.
Anke RissmannMalformation Monitoring Centre Saxony-Anhalt, Medical Faculty, Otto-von-Guericke University, 39106 Magdeburg, Germany.
Dietrich von SchweinitzDr. von Haunersches Kinderspital, Department of Paediatric Surgery, University of Munich, 80539 Munich, Germany.
Michael FrühwaldDepartment of Pediatric and Adolescent Medicine, University Medical Center Augsburg, 86159 Augsburg, Germany.ORCID 0000-0002-8237-1854
Claudia BlattmannCentre for Childhood, Adolescents and Female Medicine, Paediatrics 5 (Oncology, Hämatology, Immunology), Olgahospital Klinikum Stuttgart, 70174 Stuttgart, Germany.
Lars FischerClinic for Childhood and Adolescent Medicine, Paediatric Oncology, University Hospital Leipzig (Universitätsklinikum Leipzig AöR), 04103 Leipzig, Germany.
Björn Sönke LangeClinic for Childhood and Adolescent Medicine, Paediatric Haematology and Oncology, University Hospital Dresden, 01307 Dresden, Germany.
Rüdiger WessalowskiClinic for Paediatric Hematology, Oncology and Immunology, University Childrens Hospital Düsseldorf, 40225 Düsseldorf, Germany.
Birgit FröhlichClinic for Paediatric Hematology and Oncology, University of Münster, 48149 Münster, Germany.ORCID 0009-0005-4803-8336
Wolfgang BehnischDepartment of Paediatric Haematology and Oncology, University Childrens Hospital Heidelberg, 69120 Heidelberg, Germany.
Irene SchmidDr. von Haunersches Kinderspital, Department of Paediatric Haematology and Oncology, University of Munich, 80539 Munich, Germany.ORCID 0000-0002-5105-3597
Harald ReinhardDepartment of Paediatric Haematology and Oncology, Asklepios Hospital Sankt Augustin, 53757 St. Augustin, Germany.
Matthias DürkenClinic for Childhood and Adolescent Medicine, Paediatric Haematology and Oncology, Medical Faculty Mannheim, University of Heidelberg, 69117 Heidelberg, Germany.ORCID 0000-0002-5246-7740
Patrick HundsdörferClinic for Childhood and Adolescent Medicine, Oncology Haematology, HELIOS Clinic Berlin-Buch, 13125 Berlin, Germany.
Martin HeimbrodtDepartment of Pediatric Hematology and Oncology, University Hospital Bonn, 53127 Bonn, Germany.
Christian VokuhlDepartment of Pathology, Section Paidopathology, University Hospital Bonn, 53127 Bonn, Germany.
Stefan SchönbergerDepartment of Pediatric Hematology and Oncology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.ORCID 0000-0002-7222-296X
Dominik T SchneiderClinic of Paediatrics, Klinikum Dortmund, University Witten/Herdecke, 58448 Witten, Germany.ORCID 0000-0001-8153-1601
Guido SeitzDepartment of Pediatric Surgery and Urology, University Hospital Giessen-Marburg, Campus Marburg, 35037 Marburg, Germany.
Leendert LooijengaPrincess Máxima Center for Pediatric Oncology, 3584 Utrecht, The Netherlands.
Ulrich GöbelClinic for Paediatric Hematology, Oncology and Immunology, University Childrens Hospital Düsseldorf, 40225 Düsseldorf, Germany.
Rüdiger von KriesDivision of Epidemiology, Institute of Social Pediatrics and Adolescent Medicine, LMU Munich, 80539 Munich, Germany.
Heiko ReutterDepartment of Pediatrics and Adolescent Medicine, University Hospital Erlangen, 91054 Erlangen, Germany.ORCID 0000-0002-3591-5265
Gabriele CalaminusDepartment of Pediatric Hematology and Oncology, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0002-7893-7982

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

GCTs are developmental tumors and are likely to reflect ontogenetic and teratogenetic determinants. The objective of this study was to identify syndromes with or without congenital anomalies and non-syndromic defects as potential risk factors. Patients with extracranial GCTs (eGCTs) registered in MAKEI 96/MAHO 98 between 1996 and 2017 were included. According to Teilum's holistic concept, malignant and benign teratomas were registered. We used a case-control study design with Orphanet as a reference group for syndromic defects and the Mainz birth registry (EUROCAT) for congenital anomalies at birth. Co-occurring genetic syndromes and/or congenital anomalies were assessed accordingly. Odds ratios and 95% confidence intervals were calculated and

Indexed as

Currarino syndromedevelopmental tumorgerm cell tumorMAKEI 96/MAHO 98non-syndromic defectSwyer syndromesyndrome

Identifiers

PMID38893276
PMCPMC11172205

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.