Evidence map›Paper›PMID 38893236›Full record

ArticleCancers2024

Implementing Multifactorial Risk Assessment with Polygenic Risk Scores for Personalized Breast Cancer Screening in the Population Setting: Challenges and Opportunities.

Meghan J Walker, Kristina M Blackmore, Amy Chang, Laurence Lambert-Côté, Annie Turgeon, Antonis C Antoniou, Kathleen A Bell, Mireille J M Broeders, Jennifer D Brooks, Tim Carver and 20 more

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Trial
  2. Article
  3. Earlier screening, better outcomes? Revisiting breast cancer screening guidelines for women in their 40s.Canadian journal of public health = Revue canadienne de sante publique · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Patient and Physician Perspectives on Using Risk Prediction to Support Breast Cancer Surveillance Decision Making.Medical decision making : an international journal of the Society for Medical Decision Making · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Meghan J WalkerOntario Health (Cancer Care Ontario), Toronto, ON M5G 2L3, Canada.ORCID 0000-0003-4189-7507
Kristina M BlackmoreOntario Health (Cancer Care Ontario), Toronto, ON M5G 2L3, Canada.
Amy ChangOntario Health (Cancer Care Ontario), Toronto, ON M5G 2L3, Canada.
Laurence Lambert-CôtéCHU de Québec-Université Laval Research Center, Queébec City, QC G1V 4G2, Canada.ORCID 0000-0003-2598-7094
Annie TurgeonCHU de Québec-Université Laval Research Center, Queébec City, QC G1V 4G2, Canada.ORCID 0009-0006-7816-6133
Antonis C AntoniouCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge CB1 8RN, UK.
Kathleen A BellOntario Health (Cancer Care Ontario), Toronto, ON M5G 2L3, Canada.
Mireille J M BroedersDepartment for Health Evidence, Radboud University Medical Center, 6525EP Nijmegen, The Netherlands.ORCID 0000-0002-8741-8148
Jennifer D BrooksDalla Lana School of Public Health, University of Toronto, Toronto, ON M5S 1A1, Canada.ORCID 0000-0001-7574-4256
Tim CarverCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge CB1 8RN, UK.
Jocelyne ChiquetteCHU de Québec-Université Laval Research Center, Queébec City, QC G1V 4G2, Canada.
Philippe DesprésDepartment of Physics, Engineering Physics and Optics, Faculty of Science and Engineering, Université Laval, Quebec City, QC G1V 0A6, Canada.ORCID 0000-0002-4163-7353
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge CB1 8RN, UK.
Andrea EisenOntario Health (Cancer Care Ontario), Toronto, ON M5G 2L3, Canada.
Laurence EloyQuébec Cancer Program, Ministère de la Santé et des Services Sociaux, Quebec City, QC G1S 2M1, Canada.
D Gareth EvansDivision of Evolution Infection and Genomic Sciences, The University of Manchester, Manchester M13 9PL, UK.ORCID 0000-0002-8482-5784
Samantha FienbergOntario Health (Cancer Care Ontario), Toronto, ON M5G 2L3, Canada.
Yann JolyCentre of Genomics and Policy, McGill University, Montreal, QC H3A 0G1, Canada.
Raymond H KimOntario Health (Cancer Care Ontario), Toronto, ON M5G 2L3, Canada.ORCID 0000-0002-2147-8674
Shana J KimDalla Lana School of Public Health, University of Toronto, Toronto, ON M5S 1A1, Canada.ORCID 0009-0008-8816-5518
Bartha M KnoppersCentre of Genomics and Policy, McGill University, Montreal, QC H3A 0G1, Canada.ORCID 0000-0001-7004-2722
Aisha K LoftersDalla Lana School of Public Health, University of Toronto, Toronto, ON M5S 1A1, Canada.
Hermann NabiCHU de Québec-Université Laval Research Center, Queébec City, QC G1V 4G2, Canada.
Jean-Sébastien PaquetteDepartment of Family Medicine and Emergency Medicine, Faculty of Medicine, Université Laval, Québec City, QC G1V 0A6, Canada.ORCID 0000-0002-9524-6761
Nora PashayanCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge CB1 8RN, UK.
Amanda J SheppardOntario Health (Cancer Care Ontario), Toronto, ON M5G 2L3, Canada.
Tracy L StockleyDivision of Clinical Laboratory Genetics, University Health Network, Toronto, ON M5G 2C4, Canada.ORCID 0000-0002-4476-9722
Michel DorvalCHU de Québec-Université Laval Research Center, Queébec City, QC G1V 4G2, Canada.ORCID 0000-0002-3207-8211
Jacques SimardCHU de Québec-Université Laval Research Center, Queébec City, QC G1V 4G2, Canada.ORCID 0000-0001-6906-3390
Anna M ChiarelliOntario Health (Cancer Care Ontario), Toronto, ON M5G 2L3, Canada.

Funding

Cancer Research UK PPRPGM-Nov20\100002CHU de Québec-Université Laval Research Center N/ACIHR 155865Genome Canada 13529Génome Québec N/AOntario Research Fund N/AQuebec Breast Cancer Foundation N/Athe CHU de Québec Foundation N/A
6 · The paper itself

Abstract

Risk-stratified breast screening has been proposed as a strategy to overcome the limitations of age-based screening. A prospective cohort study was undertaken within the PERSPECTIVE I&I project, which will generate the first Canadian evidence on multifactorial breast cancer risk assessment in the population setting to inform the implementation of risk-stratified screening. Recruited females aged 40-69 unaffected by breast cancer, with a previous mammogram, underwent multifactorial breast cancer risk assessment. The adoption of multifactorial risk assessment, the effectiveness of methods for collecting risk factor information and the costs of risk assessment were examined. Associations between participant characteristics and study sites, as well as data collection methods, were assessed using logistic regression; all

Indexed as

breast cancerbreast cancer screeningimplementationpolygenic risk scorerisk assessmentrisk stratification

Identifiers

PMID38893236
PMCPMC11171515

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.