Evidence map›Paper›PMID 38893160›Full record

ArticleCancers2024

Synergistic Antitumor Activity of Talazoparib and Temozolomide in Malignant Rhabdoid Tumors.

Elena Mironova, Sebastian Molinas, Vanessa Del Pozo, Abhik M Bandyopadhyay, Zhao Lai, Dias Kurmashev, Eric L Schneider, Daniel V Santi, Yidong Chen, Raushan T Kurmasheva

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Preclinical Activity of the B7-H3-Targeting Antibody-Drug Conjugate Vobramitamab Duocarmazine in Pediatric Solid Tumors.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Elena MironovaGreehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA.ORCID 0000-0002-2579-5319
Sebastian MolinasGreehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Vanessa Del PozoGreehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Abhik M BandyopadhyayGreehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Zhao LaiGreehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Dias KurmashevGreehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Eric L SchneiderProlynx, Inc., San Francisco, CA 94107, USA.ORCID 0000-0001-7274-7961
Daniel V SantiProlynx, Inc., San Francisco, CA 94107, USA.
Yidong ChenGreehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Raushan T KurmashevaGreehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA.ORCID 0000-0003-3212-2363

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1M
A Testing Program to Identify Novel Agents for Treatment of Pediatric and AYA High-Risk Sarcoma, Kidney and Liver CancerU01CA263981 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Raushan Kurmasheva · 2021 to 2026
$3.2M
Advancing Cancer Research Through Next Generation Sequencing at Mays Cancer Center of UT Health San AntonioR50CA265339 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Zhao Lai · 2022 to 2026
$957k
Illumina NovaSeq 6000 Sequencing SystemS10OD030311 · OD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LAI, ZHAO · 2021 to 2021
$600k
Cure Childhood Cancer Association N/ANCI NIH HHS P30 CA054174NCI NIH HHS R50 CA265339NCI NIH HHS U01 CA263981NIH HHS S10 OD030311
6 · The paper itself

Abstract

Malignant rhabdoid tumors (MRTs) are among the most aggressive and treatment-resistant malignancies affecting infants, originating in the kidney, brain, liver, and soft tissues. The 5-year event-free survival rate for these cancers is a mere 20%. In nearly all cases of MRT, the

Indexed as

DNA damage and repairmalignant rhabdoid tumorPARP1pediatric cancer therapySMARCB1

Identifiers

PMID38893160
PMCPMC11171327

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.