Evidence map›Paper›PMID 38893101›Full record

ReviewCancers2024

The Role of Biomarkers in Lung Cancer Screening.

Efimia Boutsikou, Georgia Hardavella, Eleni Fili, Aikaterini Bakiri, Stylianos Gaitanakis, Alexandra Kote, Konstantinos Samitas, Ioannis Gkiozos

Abstract readReview
In one paragraph

Review in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Lung cancer screening: where do we stand?Breathe (Sheffield, England) · 2024
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Efimia BoutsikouDepartment of Respiratory Medicine and Oncology, "Theageneio" Anti-Cancer Hospital of Thessaloniki, AL. Simeonidi Str., 54639 Thessaloniki, Greece.
Georgia Hardavella4th-9th Department of Respiratory Medicine, "Sotiria" Athens' Chest Diseases Hospital, 152 Mesogeion Av., 11527 Athens, Greece.
Eleni FiliHealth Sciences Library, "Sotiria" Athens' Chest Diseases Hospital, 152 Mesogeion Av., 11527 Athens, Greece.ORCID 0009-0009-2036-2598
Aikaterini Bakiri1st University Department of Respiratory Medicine, "Sotiria" Athens' Chest Diseases Hospital, 152 Mesogeion Av., 11527 Athens, Greece.ORCID 0000-0002-4122-652X
Stylianos GaitanakisDepartment of Thoracic Surgery, 401 Hellenic Army Hospital, Panagiotis Kanellopoulos Av., 11525 Athens, Greece.
Alexandra Kote6th Department of Respiratory Medicine, "Sotiria" Athens' Chest Diseases Hospital, 152 Mesogeion Av., 11527 Athens, Greece.
Konstantinos Samitas7th Department of Respiratory Medicine, "Sotiria" Athens' Chest Diseases Hospital, 152 Mesogeion Av., 11527 Athens, Greece.
Ioannis GkiozosOncology Unit, 3rd University Department of Internal Medicine, "Sotiria" Athens' Chest Diseases Hospital, 152 Mesogeion Av., 11527 Athens, Greece.ORCID 0000-0002-2902-3391

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLung Cancer Screening (LCS) is an evolving field with variations in its implementation in various countries. There are only scarce data from National LCS programs.

aimWe aim to provide an up-to-date overview of the current evidence regarding the use of biomarkers in LCS. MATERIALS AND

methodsA multidisciplinary Task Force experts' panel collaborated and conducted a systematic literature search, followed by screening, review and synthesis of available evidence.

resultsBiomarkers in LCS could be used to improve risk stratification in high-risk participants, improve clarification regarding indeterminate lung nodules and avoid overdiagnosis in suspicious lung findings. Currently, there seem to be promising biomarkers (blood/serum/breath) that have been studied in various trials; however, there is still a lack of solid evidence in clinical validation that would pave the way for their integration into LCS programs.

conclusionsBiomarkers are the next logical step in improving the LCS pathway and its efficiency by playing an adjuvant role in a minimally invasive way. National LCS programs and pilot studies should integrate biomarkers to validate their accuracy in real-life LCS participants.

Indexed as

biomarkersbloodimplementationlung cancerrisk stratificationscreeningserumvolatile organic compounds

Identifiers

PMID38893101
PMCPMC11171002

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.