Evidence map›Paper›PMID 38892720›Full record

ArticleNutrients2024

Blood Iodine as a Potential Marker of the Risk of Cancer in BRCA1 Carriers.

Adam Kiljańczyk, Milena Matuszczak, Wojciech Marciniak, Róża Derkacz, Klaudia Stempa, Piotr Baszuk, Marta Bryśkiewicz, Cezary Cybulski, Tadeusz Dębniak, Jacek Gronwald and 20 more

Abstract read
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Adam KiljańczykDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.
Milena MatuszczakDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.ORCID 0000-0001-8050-1507
Wojciech MarciniakRead-Gene, Grzepnica, ul. Alabastrowa 8, 72-003 Dobra, Poland.ORCID 0000-0001-7270-0063
Róża DerkaczRead-Gene, Grzepnica, ul. Alabastrowa 8, 72-003 Dobra, Poland.ORCID 0000-0002-2904-5259
Klaudia StempaDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.ORCID 0000-0002-1909-9333
Piotr BaszukDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.ORCID 0000-0002-0676-2597
Marta BryśkiewiczDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.
Cezary CybulskiDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.
Tadeusz DębniakDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.ORCID 0000-0002-3506-8932
Jacek GronwaldDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.ORCID 0000-0002-3643-2871
Tomasz HuzarskiDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.
Marcin R LenerDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.
Anna JakubowskaDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.
Angela CheriyanWomen's College Research Institute, Women's College Hospital, University of Toronto, Toronto, ON M5G 1N8, Canada.
Marek SzwiecDepartment of Surgery and Oncology, University of Zielona Góra, Zyty 28, 65-046 Zielona Góra, Poland.ORCID 0000-0001-6981-6356
Małgorzata Stawicka-NiełacnaDepartment of Clinical Genetics and Pathology, University of Zielona Góra, ul. Zyty 28, 65-046 Zielona Góra, Poland.ORCID 0000-0003-3076-9892
Dariusz GodlewskiOPEN, Kazimierza Wielkiego 24 St, 61-863 Poznań, Poland.
Artur PrusaczykMedical and Diagnostic Center, 08-110 Siedlce, Poland.
Andrzej JasiewiczGenetic Counseling Center, Subcarpatian Oncological Hospital, 18 Bielawskiego St, 36-200 Brzozów, Poland.ORCID 0000-0002-1581-8791
Tomasz KluzDepartment of Gynecology, Gynecology Oncology and Obstetrics, Institute of Medical Sciences, Medical College of Rzeszow University, Rejtana 16c, 35-959 Rzeszow, Poland.ORCID 0000-0002-4798-3986
Joanna Tomiczek-SzwiecDepartment of Histology, Department of Biology and Genetics, Faculty of Medicine, University of Opole, 45-040 Opole, Poland.ORCID 0000-0001-8908-6610
Ewa Kilar-KobierzyckaDepartment of Oncology, District Specialist Hospital, Leśna 27-29 St, 58-100 Świdnica, Poland.
Monika SiołekHolycross Cancer Center, Artwińskiego 3 St, 25-734 Kielce, Poland.
Rafał WiśniowskiRegional Oncology Hospital, Wyzwolenia 18 St, 43-300 Bielsko Biała, Poland.
Renata PosmykDepartment of Clinical Genetics, Medical University of Bialystok, 15-089 Bialystok, Poland.
Joanna Jarkiewicz-TretynNon-Public Health Care Centre, Cancer Genetics Laboratory, 87-100 Toruń, Poland.
Ping SunWomen's College Research Institute, Women's College Hospital, University of Toronto, Toronto, ON M5G 1N8, Canada.
Rodney J ScottMedical Genetics, Hunter Medical Research Institute, Priority Research Centre for Cancer Research, Innovation and Translation, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Pathology North, John Hunter Hospital, King and Auckland Streets, Newcastle, NSW 2300, Australia.ORCID 0000-0001-7724-3404
Steven A NarodWomen's College Research Institute, Women's College Hospital, University of Toronto, Toronto, ON M5G 1N8, Canada.ORCID 0000-0001-5798-0626
Jan LubińskiDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.ORCID 0000-0003-2931-3003

Funding

Minister of Science and Higher Education 002/RID/2018/19
6 · The paper itself

Abstract

Breast cancer and ovarian cancer pose a significant risk for BRCA1 carriers, with limited risk-reduction strategies. While improved screening helps in the early detection of breast cancer, preventive measures remain elusive. Emerging evidence suggests a potential link between iodine levels and modulation of cancer risk, but comprehensive studies are scarce. We conducted a prospective study among 989 BRCA1 carriers to assess the association between blood iodine levels and breast and ovarian cancer risk. Using inductively coupled plasma mass spectrometry, we measured blood iodine levels and observed a negative association with breast cancer risk, with a significantly lower risk observed in quartile 4 (iodine > 38.0 µg/L) compared with quartile 1 (iodine < 30 µg/L) (HR = 0.49; 95%CI: 0.27-0.87;

Indexed as

BRCA1 ProteinBreast NeoplasmsIodineOvarian NeoplasmsAdultAgedBiomarkers, TumorFemaleHeterozygoteHumansMiddle AgedProspective StudiesRisk FactorsBiomarkers, TumorBRCA1 ProteinBRCA1 protein, humanIodineBRCA1breast cancercancermicroelementsnutrientsovarian cancer

Identifiers

PMID38892720
PMCPMC11174800

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.