Evidence map›Paper›PMID 38892698›Full record

ArticleNutrients2024

Longitudinal Analysis of One-Carbon Metabolism-Related Metabolites in Maternal and Cord Blood of Japanese Pregnant Women.

Yoshinori Kubo, Hideoki Fukuoka, Kumiko Shoji, Chisato Mori, Kenichi Sakurai, Masazumi Nishikawa, Kyoichi Oshida, Yuichiro Yamashiro, Terue Kawabata

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yoshinori KuboFaculty of Nutrition, Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado 350-0288, Saitama, Japan.ORCID 0000-0002-3316-1607
Hideoki FukuokaDepartment of Perinatal Mesenchymal Stem Cell Research, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Fukushima, Japan.
Kumiko ShojiFaculty of Nutrition, Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado 350-0288, Saitama, Japan.
Chisato MoriDepartment of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Chiba, Japan.ORCID 0000-0002-1144-8316
Kenichi SakuraiDepartment of Nutrition and Metabolic Medicine, Center for Preventive Medical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Chiba, Japan.
Masazumi NishikawaDepartment of Food Management, School of Food, Agricultural and Environmental Sciences, Miyagi University, 2-2-1 Hatadate, Taihaku-ku, Sendai 982-0215, Miyagi, Japan.ORCID 0009-0000-5146-2174
Kyoichi OshidaFaculty of Beauty & Wellness, Professional University of Beauty & Wellness, 3-9-3 Ushikubo, Tsuzuki-ku, Yokohama 224-0012, Kanagawa, Japan.ORCID 0009-0001-4574-4498
Yuichiro YamashiroProbiotics Research Laboratory, Graduate School of Medicine, Juntendo University, 2-9-8-3F, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Terue KawabataFaculty of Nutrition, Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado 350-0288, Saitama, Japan.

Funding

Japan Society for the Promotion of Science 19K11699Laboratory for Probiotics Research, Juntendo University School of Medicine None
6 · The paper itself

Abstract

One-carbon metabolism (OCM) is a complex and interconnected network that undergoes drastic changes during pregnancy. In this study, we investigated the longitudinal distribution of OCM-related metabolites in maternal and cord blood and explored their relationships. Additionally, we conducted cross-sectional analyses to examine the interrelationships among these metabolites. This study included 146 healthy pregnant women who participated in the Chiba Study of Mother and Child Health. Maternal blood samples were collected during early pregnancy, late pregnancy, and delivery, along with cord blood samples. We analyzed 18 OCM-related metabolites in serum using stable isotope dilution liquid chromatography/tandem mass spectrometry. We found that serum S-adenosylmethionine (SAM) concentrations in maternal blood remained stable throughout pregnancy. Conversely, S-adenosylhomocysteine (SAH) concentrations increased, and the total homocysteine/total cysteine ratio significantly increased with advancing gestational age. The betaine/dimethylglycine ratio was negatively correlated with total homocysteine in maternal blood for all sampling periods, and this correlation strengthened with advances in gestational age. Most OCM-related metabolites measured in this study showed significant positive correlations between maternal blood at delivery and cord blood. These findings suggest that maternal OCM status may impact fetal development and indicate the need for comprehensive and longitudinal evaluations of OCM during pregnancy.

Indexed as

Fetal BloodHomocysteineS-AdenosylmethionineAdultBetaineCarbonCross-Sectional StudiesCysteineEast Asian PeopleFemaleGestational AgeGlycineHumansJapanLongitudinal StudiesPregnancyBetaineCarbonCysteinedimethylglycineGlycineHomocysteineS-AdenosylhomocysteineS-AdenosylmethionineSarcosine5-methyltetrahydrofolatebetainecysteinehomocysteinemethionineone-carbon metabolismpregnant womanS-adenosylhomocysteineS-adenosylmethioninetranssulfuration pathway

Identifiers

PMID38892698
PMCPMC11174998

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.