Evidence map›Paper›PMID 38892576›Full record

ArticleNutrients2024

Association between Urine Specific Gravity as a Measure of Hydration Status and Risk of Type 2 Diabetes: The Kailuan Prospective Cohort Study.

Yinqiao Dong, Shuohua Chen, Yaohui Yu, Wenjuan Li, Zhongqing Xu, Juan Du, Shan Huang, Shouling Wu, Yong Cai

Abstract read
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yinqiao DongSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID 0000-0002-3713-3590
Shuohua ChenDepartment of Cardiology, Kailuan General Hospital, North China University of Science and Technology, Tangshan 063000, China.
Yaohui YuSchool of Public Health, North China University of Science and Technology, Tangshan 063210, China.
Wenjuan LiSchool of Clinical Medicine, North China University of Science and Technology, Tangshan 063210, China.
Zhongqing XuDepartment of General Practice, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200335, China.
Juan DuEndocrinology Department, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200335, China.
Shan HuangEndocrinology Department, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200335, China.
Shouling WuDepartment of Cardiology, Kailuan General Hospital, North China University of Science and Technology, Tangshan 063000, China.ORCID 0000-0001-7095-6022
Yong CaiPublic Health Department, Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200335, China.ORCID 0000-0002-5706-7906

Funding

National Key Research and Development Program of China 2021YFC2701900, 2021YFC2701903Shanghai Health Commission GWVI-11.1-29, GWV-10.1-XK18, GWV-10.2-XD13
6 · The paper itself

Abstract

Diabetes, especially type 2 diabetes (T2D), poses an unprecedented challenge to global public health. Hydration status also plays a fundamental role in human health, especially in people with T2D, which is often overlooked. This study aimed to explore the longitudinal associations between hydration status and the risk of T2D among the Chinese population. This study used data from the large community-based Kailuan cohort, which included adults who attended physical examinations from 2006 to 2007 and were followed until 2020. A total of 71,526 participants who eventually met the standards were divided into five hydration-status groups based on their levels of urine specific gravity (USG). Multivariable and time-dependent Cox proportional hazards models were employed to evaluate the associations of baseline and time-dependent hydration status with T2D incidence. Restricted cubic splines (RCS) analysis was used to examine the dose-response relationship between hydration status and the risk of T2D. Over a median 12.22-year follow-up time, 11,804 of the participants developed T2D. Compared with the optimal hydration-status group, participants with dehydration and severe dehydration had a significantly increased risk of diabetes, with adjusted hazard ratios (95% CI) of 1.30 (1.04-1.63) and 1.38 (1.10-1.74). Time-dependent analyses further confirmed the adverse effects of impending dehydration, dehydration, and severe dehydration on T2D incidence by 16%, 26%, and 33% compared with the reference group. Inadequate hydration is significantly associated with increased risks of T2D among Chinese adults. Our findings provided new epidemiological evidence and highlighted the potential role of adequate hydration status in the early prevention of T2D development.

Indexed as

DehydrationDiabetes Mellitus, Type 2Specific GravityAdultAgedChinaFemaleHumansIncidenceMaleMiddle AgedOrganism Hydration StatusProportional Hazards ModelsProspective StudiesRisk FactorsUrinalysiscohort studydehydrationhydration statustime-dependenttype 2 diabetes

Identifiers

PMID38892576
PMCPMC11174895

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.