Evidence map›Paper›PMID 38892560›Full record

ArticleNutrients2024

Genome-Wide Admixture and Association Study of Serum Selenium Deficiency to Identify Genetic Variants Indirectly Linked to Selenium Regulation in Brazilian Adults.

Ligia Moriguchi Watanabe, Lisete Sousa, Francisco M Couto, Natália Yumi Noronha, Marcela Augusta de Souza Pinhel, Gleyson Francisco da Silva Carvalho, Guilherme da Silva Rodrigues, Carlos Roberto Bueno Júnior, Leslie Domenici Kulikowski, Fernando Barbosa Júnior and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ligia Moriguchi WatanabeDivision of Nutrition and Metabolism, Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo-FMRP/USP, São Paulo 14049-900, Brazil.ORCID 0000-0001-7498-6165
Lisete SousaDepartamento de Estatística e Investigação Operacional (DEIO) e Centro de Estatística e Aplicações (CEAUL), Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016 Lisbon, Portugal.ORCID 0000-0002-2114-720X
Francisco M CoutoLASIGE, Departamento de Informática, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016 Lisbon, Portugal.ORCID 0000-0003-0627-1496
Natália Yumi NoronhaDepartment of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo-FMRP/USP, São Paulo 14049-900, Brazil.ORCID 0000-0001-9589-8586
Marcela Augusta de Souza PinhelDepartment of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo-FMRP/USP, São Paulo 14049-900, Brazil.ORCID 0000-0003-3645-3709
Gleyson Francisco da Silva CarvalhoDepartment of Pathology, São Paulo Medical School, University of São Paulo-FMUSP, São Paulo 01246-903, Brazil.
Guilherme da Silva RodriguesSchool of Physical Education and Sport of Ribeirão Preto, University of São Paulo, São Paulo 14040-900, Brazil.ORCID 0000-0002-9931-4709
Carlos Roberto Bueno JúniorSchool of Physical Education and Sport of Ribeirão Preto, University of São Paulo, São Paulo 14040-900, Brazil.
Leslie Domenici KulikowskiDepartment of Pathology, São Paulo Medical School, University of São Paulo-FMUSP, São Paulo 01246-903, Brazil.ORCID 0000-0003-2236-3956
Fernando Barbosa JúniorDepartment of Clinical and Toxicological Analyses and Bromatology, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo-FCFRP/USP, São Paulo 14040-900, Brazil.ORCID 0000-0002-2498-0619
Carla Barbosa NoninoDivision of Nutrition and Metabolism, Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo-FMRP/USP, São Paulo 14049-900, Brazil.

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/24069-3Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/15196-4
6 · The paper itself

Abstract

Blood selenium (Se) concentrations differ substantially by population and could be influenced by genetic variants, increasing Se deficiency-related diseases. We conducted a genome-wide association study (GWAS) to identify single nucleotide polymorphisms (SNPs) associated with serum Se deficiency in 382 adults with admixed ancestry. Genotyping arrays were combined to yield 90,937 SNPs. R packages were applied to quality control and imputation. We also performed the ancestral proportion analysis. The Search Tool for the Retrieval of Interacting Genes was used to interrogate known protein-protein interaction networks (PPIs). Our ancestral proportion analysis estimated 71% of the genome was from Caucasians, 22% was from Africans, and 8% was from East Asians. We identified the SNP rs1561573 in the TraB domain containing 2B (

Indexed as

Genome-Wide Association StudyPolymorphism, Single NucleotideSeleniumAdultAfrican PeopleBrazilEast Asian PeopleFemaleGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedProtein Interaction MapsWhite PeopleSeleniumadmixed populationGWASselenium deficiency

Identifiers

PMID38892560
PMCPMC11175099

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.