Evidence map›Paper›PMID 38892396›Full record

ArticleInternational journal of molecular sciences2024

Arrhythmogenic Ventricular Remodeling by Next-Generation Bruton's Tyrosine Kinase Inhibitor Acalabrutinib.

Yanan Zhao, Praloy Chakraborty, Julianna Tomassetti, Tasnia Subha, Stéphane Massé, Paaladinesh Thavendiranathan, Filio Billia, Patrick F H Lai, Husam Abdel-Qadir, Kumaraswamy Nanthakumar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Cardiovascular Toxicity of BTKi in Chronic B-Cell Malignancies.Reviews in cardiovascular medicine · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yanan ZhaoToronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 2M1, Canada.ORCID 0000-0002-4611-9678
Praloy ChakrabortyToronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 2M1, Canada.
Julianna TomassettiToronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 2M1, Canada.
Tasnia SubhaToronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 2M1, Canada.
Stéphane MasséToronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 2M1, Canada.ORCID 0000-0003-4081-0406
Paaladinesh ThavendiranathanToronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 2M1, Canada.
Filio BilliaToronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 2M1, Canada.ORCID 0000-0002-2824-1215
Patrick F H LaiToronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 2M1, Canada.ORCID 0000-0002-8355-7183
Husam Abdel-QadirToronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 2M1, Canada.
Kumaraswamy NanthakumarToronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 2M1, Canada.

Funding

CIHR PJT 190317
6 · The paper itself

Abstract

Cardiac arrhythmias remain a significant concern with Ibrutinib (IBR), a first-generation Bruton's tyrosine kinase inhibitor (BTKi). Acalabrutinib (ABR), a next-generation BTKi, is associated with reduced atrial arrhythmia events. However, the role of ABR in ventricular arrhythmia (VA) has not been adequately evaluated. Our study aimed to investigate VA vulnerability and ventricular electrophysiology following chronic ABR therapy in male Sprague-Dawley rats utilizing epicardial optical mapping for ventricular voltage and Ca

Indexed as

Agammaglobulinaemia Tyrosine KinaseArrhythmias, CardiacBenzamidesPiperidinesRats, Sprague-DawleyAction PotentialsAdenineAnimalsCalciumCalcium SignalingHeart VentriclesMaleProtein Kinase InhibitorsPyrazinesPyrazolesPyrimidinesacalabrutinibAdenineAgammaglobulinaemia Tyrosine KinaseBenzamidesCalciumibrutinibPiperidinesProtein Kinase InhibitorsPyrazinesPyrazolesPyrimidinesSarcoplasmic Reticulum Calcium-Transporting ATPasesTyrosine Kinase Inhibitorsacalabrutinibaction potentialcalcium cyclingelectrical remodelingibrutinibventricular arrhythmia

Identifiers

PMID38892396
PMCPMC11173147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.