Evidence map›Paper›PMID 38892380›Full record

ArticleInternational journal of molecular sciences2024

Levosimendan's Effects on Length-Dependent Activation in Murine Fast-Twitch Skeletal Muscle.

Michael Haug, Mena Michael, Paul Ritter, Larisa Kovbasyuk, Maria Eleni Vazakidou, Oliver Friedrich

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michael HaugInstitute of Medical Biotechnology, Department of Chemical and Biological Engineering, Friedrich-Alexander-University Erlangen-Nürnberg, Paul-Gordan Str. 3, 91052 Erlangen, Germany.ORCID 0000-0001-5968-2593
Mena MichaelInstitute of Medical Biotechnology, Department of Chemical and Biological Engineering, Friedrich-Alexander-University Erlangen-Nürnberg, Paul-Gordan Str. 3, 91052 Erlangen, Germany.ORCID 0000-0003-4805-0333
Paul RitterInstitute of Medical Biotechnology, Department of Chemical and Biological Engineering, Friedrich-Alexander-University Erlangen-Nürnberg, Paul-Gordan Str. 3, 91052 Erlangen, Germany.ORCID 0000-0001-9227-8031
Larisa KovbasyukInstitute of Medical Biotechnology, Department of Chemical and Biological Engineering, Friedrich-Alexander-University Erlangen-Nürnberg, Paul-Gordan Str. 3, 91052 Erlangen, Germany.
Maria Eleni VazakidouInstitute of Medical Biotechnology, Department of Chemical and Biological Engineering, Friedrich-Alexander-University Erlangen-Nürnberg, Paul-Gordan Str. 3, 91052 Erlangen, Germany.
Oliver FriedrichInstitute of Medical Biotechnology, Department of Chemical and Biological Engineering, Friedrich-Alexander-University Erlangen-Nürnberg, Paul-Gordan Str. 3, 91052 Erlangen, Germany.ORCID 0000-0003-2238-2049

Funding

Erlangen Graduate School in Advanced Optical Technologies GSC 80
6 · The paper itself

Abstract

Levosimendan's calcium sensitizing effects in heart muscle cells are well established; yet, its potential impact on skeletal muscle cells has not been evidently determined. Despite controversial results, levosimendan is still expected to interact with skeletal muscle through off-target sites (further than troponin C). Adding to this debate, we investigated levosimendan's acute impact on fast-twitch skeletal muscle biomechanics in a length-dependent activation study by submersing single muscle fibres in a levosimendan-supplemented solution. We employed our

Indexed as

CalciumMuscle Fibers, Fast-TwitchSimendanAnimalsMaleMiceMuscle ContractionMyofibrilsSarcomeresCalciumSimendancalcium sensitivitylevosimendanMyoRobotsingle muscle fibrestress–strain

Identifiers

PMID38892380
PMCPMC11172453

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.