Evidence map›Paper›PMID 38892320›Full record

ArticleInternational journal of molecular sciences2024

Knockdown of Esr1 from DRD1-Rich Brain Regions Affects Adipose Tissue Metabolism: Potential Crosstalk between Nucleus Accumbens and Adipose Tissue.

Dusti Shay, Rebecca Welly, Jiude Mao, Jessica Kinkade, Joshua K Brown, Cheryl S Rosenfeld, Victoria J Vieira-Potter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dusti ShayDepartment of Nutrition and Exercise Physiology, Division of Food, Nutrition and Exercise Sciences, CAFNR, University of Missouri, Columbia, MO 65211, USA.
Rebecca WellyDepartment of Nutrition and Exercise Physiology, Division of Food, Nutrition and Exercise Sciences, CAFNR, University of Missouri, Columbia, MO 65211, USA.
Jiude MaoBiomedical Sciences, University of Missouri, E102 Veterinary Medicine Building, Columbia, MO 65211, USA.
Jessica KinkadeBiomedical Sciences, University of Missouri, E102 Veterinary Medicine Building, Columbia, MO 65211, USA.
Joshua K BrownDepartment of Nutrition and Exercise Physiology, Division of Food, Nutrition and Exercise Sciences, CAFNR, University of Missouri, Columbia, MO 65211, USA.
Cheryl S RosenfeldBiomedical Sciences, University of Missouri, E102 Veterinary Medicine Building, Columbia, MO 65211, USA.ORCID 0000-0002-4137-3933
Victoria J Vieira-PotterDepartment of Nutrition and Exercise Physiology, Division of Food, Nutrition and Exercise Sciences, CAFNR, University of Missouri, Columbia, MO 65211, USA.ORCID 0000-0001-7563-0806

Funding

The Role of Estradiol on Central Dopamine Signaling and its Associations with Cocaine Preference and ExerciseF31DA055452 · NIDA · UNIVERSITY OF MISSOURI-COLUMBIA · PI SHAY, DUSTI · 2022 to 2023
$68k
NIDA NIH HHS F31 DA055452NIH HHS 1F31DA055452-23A1
6 · The paper itself

Abstract

Declining estrogen (E2) leads to physical inactivity and adipose tissue (AT) dysfunction. Mechanisms are not fully understood, but E2's effects on dopamine (DA) activity in the nucleus accumbens (NAc) brain region may mediate changes in mood and voluntary physical activity (PA). Our prior work revealed that loss of E2 robustly affected NAc DA-related gene expression, and the pattern correlated with sedentary behavior and visceral fat. The current study used a new transgenic mouse model (D1ERKO) to determine whether the abolishment of E2 receptor alpha (ERα) signaling within DA-rich brain regions affects PA and AT metabolism. Adult male and female wild-type (WT) and D1ERKO (KD) mice were assessed for body composition, energy intake (EE), spontaneous PA (SPA), and energy expenditure (EE); underwent glucose tolerance testing; and were assessed for blood biochemistry. Perigonadal white AT (PGAT), brown AT (BAT), and NAc brain regions were assessed for genes and proteins associated with DA, E2 signaling, and metabolism; AT sections were also assessed for uncoupling protein (UCP1). KD mice had greater lean mass and EE (genotype effects) and a visible change in BAT phenotype characterized by increased UCP1 staining and lipid depletion, an effect seen only among females. Female KD had higher NAc

Indexed as

Adipose TissueEnergy MetabolismEstrogen Receptor alphaNucleus AccumbensReceptors, Dopamine D1Adipose Tissue, BrownAnimalsBrainFemaleGene Knockdown TechniquesMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicUncoupling Protein 1Drd1 protein, mouseEsr1 protein, mouseEstrogen Receptor alphaReceptors, Dopamine D1Uncoupling Protein 1adipose tissuebrown adipose tissueestrogenmenopausemetabolismmidbrain regionphysical activityreward pathway

Identifiers

PMID38892320
PMCPMC11172510

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.